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Intravascular Cutaneous Disorders. A Clinicopathologic Review
Pedro Vilas Boas1, Lorenzo Cerroni2, Luis Requena1
1Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain; and.
The American Journal of Dermatopathology
|July 4, 2020
Summary
This review details skin’s intravascular proliferations, focusing on clinicopathologic and immunohistochemical features. It aids in differentiating various benign and malignant conditions affecting dermal vessels.
Area of Science:
- Dermatopathology
- Vascular Biology
- Oncology
Background:
- Intravascular skin proliferations exhibit diverse clinical and histopathological features.
- Differentiating these entities requires understanding cell types and vessel involvement.
- Immunohistochemistry is crucial for accurate diagnosis.
Purpose of the Study:
- To review clinicopathologic and immunohistochemical characteristics of various intravascular skin proliferations.
- To provide a diagnostic framework for distinguishing benign from malignant intralymphatic lesions.
- To highlight the role of immunohistochemistry in identifying intravascular proliferating cells.
Main Methods:
- Comprehensive literature review of clinicopathologic and immunohistochemical studies.
- Analysis of key features for intravascular large cell lymphoma, lymphoproliferative disorders, and vascular tumors.
- Comparative evaluation of diagnostic markers for intralymphatic histiocytosis and reactive angioendotheliomatosis.
Main Results:
- Detailed characterization of entities including Dabska tumor, Masson phenomenon, and Merkel cell carcinoma.
- Emphasis on distinguishing CD30+ lymphoproliferative disorders from benign T-cell proliferations.
- Identification of specific immunohistochemical profiles for various intravascular proliferations.
Conclusions:
- Accurate diagnosis of intravascular skin proliferations relies on integrated clinicopathologic and immunohistochemical assessment.
- Immunohistochemistry is essential for classifying T-cell/NK-cell lymphomas and differentiating reactive conditions.
- This review provides a guide for diagnosing a spectrum of intralymphatic vascular and lymphoid lesions.
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