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Related Concept Videos

Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

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The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
208
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

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Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
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Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

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Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
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Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

588
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
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Pancreatic Juice and Secretion01:26

Pancreatic Juice and Secretion

2.5K
Pancreatic juice is a clear fluid produced by the pancreas, containing water, salts, sodium bicarbonate, and enzymes vital for digestion in the small intestine. It helps break down large molecules, facilitating nutrient absorption.
When acidic chyme from the stomach enters the duodenum, it triggers the release of secretin, a hormone that prompts pancreatic juice secretion. After a fatty meal, cholecystokinin, another hormone, stimulates gallbladder contraction and enhances enzyme-rich...
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Related Experiment Video

Updated: Dec 16, 2025

Normothermic Ex Vivo Pancreas Perfusion for the Preservation of Pancreas Allografts before Transplantation
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Pancreas preservation: clinical practice and future developments.

Julien Branchereau1,2,3, James Hunter3, Peter Friend3

  • 1Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes.

Current Opinion in Organ Transplantation
|July 4, 2020
PubMed
Summary
This summary is machine-generated.

New organ preservation methods, including machine perfusion, show promise for pancreas transplantation. These strategies may expand the donor pool and improve the use of extended criteria and DCD organs.

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Area of Science:

  • Transplantation immunology
  • Organ preservation science
  • Surgical innovation

Background:

  • Donor organ shortage necessitates the use of extended criteria donors (ECDs) and donors after cardiac death (DCD).
  • Static cold storage (SCS) with University of Wisconsin solution is the current standard for pancreas preservation.
  • Emerging research explores oxygen delivery and machine perfusion to mitigate preservation-induced tissue injury.

Purpose of the Study:

  • To review recent advancements in pancreas preservation strategies.
  • To evaluate the potential of machine perfusion techniques in pancreas transplantation.
  • To assess the impact of novel preservation methods on organ utilization.

Main Methods:

  • Review of recently published studies on pancreas preservation.
  • Analysis of experimental data on machine perfusion (hypothermic and normothermic).
  • Examination of clinical data on pancreas transplantation using novel preservation.

Main Results:

  • Hypothermic machine perfusion improved ATP levels in discarded pancreases compared to SCS.
  • Normothermic machine perfusion has presented challenges, often leading to increased organ injury.
  • Limited clinical data exists, with some pancreases transplanted after normothermic regional perfusion.

Conclusions:

  • Novel organ preservation strategies, particularly machine perfusion, are under investigation for pancreas transplantation.
  • These advanced methods hold potential for expanding the donor pool and increasing the utilization of ECD and DCD organs.
  • Further clinical research is needed to validate the efficacy and safety of these emerging preservation techniques.