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Related Concept Videos

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Sustained Administration of β-cell Mitogens to Intact Mouse Islets Ex Vivo Using Biodegradable Poly(lactic-co-glycolic acid) Microspheres
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The artificial pancreas.

Charlotte K Boughton1, Roman Hovorka

  • 1Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, UK.

Current Opinion in Organ Transplantation
|July 4, 2020
PubMed
Summary

Artificial pancreas systems, also known as closed-loop systems, are revolutionizing type 1 diabetes management. While current hybrid systems show promise, further advancements are needed for complete automation and reduced patient burden.

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Area of Science:

  • Biomedical Engineering
  • Endocrinology
  • Diabetes Technology

Background:

  • Artificial pancreas (closed-loop) systems represent a significant advancement in diabetes management.
  • These systems leverage technological progress to improve glycemic control for individuals with diabetes.

Purpose of the Study:

  • To review key studies supporting the clinical adoption of artificial pancreas systems.
  • To identify current challenges and future directions for artificial pancreas technology.

Main Methods:

  • Review of pivotal clinical studies demonstrating the safety and efficacy of closed-loop insulin delivery.
  • Analysis of regulatory approvals and real-world performance data.

Main Results:

  • Closed-loop systems have proven safe and effective in free-living conditions for up to six months in type 1 diabetes patients.
  • Four hybrid closed-loop systems have received global regulatory approval since 2017.
  • Current systems require user input for mealtime insulin, highlighting a usability challenge.

Conclusions:

  • The artificial pancreas is emerging as the gold standard for type 1 diabetes treatment.
  • Widespread clinical adoption of first-generation systems is underway.
  • Further development of advanced systems and rapid-acting insulins is crucial for full automation and reduced diabetes burden.