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Zebrafish models of impulsivity and impulse control disorders
Murilo S de Abreu1,2, Ana C V V Giacomini1,3, Rafael Genario1
1Bioscience Institute, University of Passo Fundo, Passo Fundo, Brazil.
The European Journal of Neuroscience
|July 4, 2020
Summary
Zebrafish models offer valuable insights into impulse control disorders (ICDs), a group of central nervous system (CNS) conditions. Further development of these models is crucial for understanding ICDs and finding new treatments.
Area of Science:
- Neuroscience
- Behavioral Science
- Pharmacology
Background:
- Impulse control disorders (ICDs) involve difficulties in controlling emotions and behaviors.
- ICDs encompass a range of central nervous system (CNS) disorders with complex, poorly understood pathobiology.
- Currently, no specific therapies exist for ICDs.
Purpose of the Study:
- To summarize experimental models of impulsivity and ICDs in zebrafish.
- To highlight the translational significance of zebrafish models for studying ICDs.
- To emphasize the need for further development of zebrafish ICD models.
Main Methods:
- Review of existing literature on zebrafish models of impulsivity and ICDs.
- Analysis of zebrafish genetic and physiological homology to mammals.
- Consideration of zebrafish sensitivity to pharmacological and genetic manipulations.
Main Results:
- Zebrafish serve as a useful model organism for studying CNS disorders.
- Zebrafish models demonstrate potential for studying aberrant impulsivity.
- Existing zebrafish models show translational significance for ICD research.
Conclusions:
- Zebrafish models are valuable tools for investigating ICD pathobiology.
- Further development of zebrafish ICD models is essential for advancing research.
- Enhanced zebrafish models can aid in discovering novel therapeutic treatments for ICDs.
