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Updated: Dec 16, 2025
Synthesis of Indoxyl-glycosides for Detection of Glycosidase Activities
Published on: May 27, 2015
A new indole alkaloid from the stems of Glycosmis puberula var. craibii
Qi Zhou1, Chun-Xiao Jiang1, Shou-Yuan Wu2
1Institute of Natural Medicine and Health Products, Zhejiang Provincial Key Laboratory of Plant Evolutionary Ecology and Conservation, School of Advanced Study, Taizhou University, Taizhou, P. R. China.
Abstract:
A phytochemical investigation on the stems of Glycosmis puberula var. craibii led to the isolation of a new indole alkaloid (named glycosmiscrol A, 1), together with four known compounds (2-5). The new structure was elucidated by detailed analysis of comprehensive spectroscopic methods. All isolated compounds were evaluated for their antiproliferative activities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. Compounds 1-5 showed significant antiproliferative effects with IC50 values ranging from 0.16 to 8.58 µM.
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