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Adverse effects of circadian desynchrony on the male reproductive system: an epidemiological and experimental study

Kun Liu1, Guizhong Hou1,2, Xiaogang Wang3

  • 1Key Lab of Medical Protection for Electromagnetic Radiation, Ministry of Education of China, Institute of Toxicology, College of Preventive Medicine, Third Military Medical University (Army Medical University), Chongqing 400038, China.

Human Reproduction (Oxford, England)
|July 4, 2020
PubMed
Abstract

Insights

Circadian desynchrony, common in shift work, significantly lowers sperm count in men. This damage is reversible when sleep-wake cycles are restored, suggesting a preventable risk factor for male infertility.

Area of Science:

  • Reproductive Biology
  • Chronobiology
  • Occupational Health

Background:

  • Circadian desynchrony, arising from shift work and lifestyle, is a global concern.
  • While linked to female fertility issues, its impact on male reproductive health remains largely unexamined.

Purpose of the Study:

  • To investigate if circadian desynchrony is a risk factor for male reproductive damage.
  • To analyze effects on semen parameters and reproductive hormones in humans and animal models.

Main Methods:

  • A hybrid approach combining cross-sectional and cohort studies in Chinese men (n=1346 and n=796).
  • Analysis of 14-17 semen/hormone biomarkers.
  • Validation in a mouse model simulating circadian desynchrony using molecular analyses.

Main Results:

  • Lower sperm count observed in shift workers, with increased risk of low sperm count.
  • Circadian desynchrony correlated with reduced sperm count in undergraduates, which improved upon desynchrony reduction.
  • Mouse models showed decreased sperm count during desynchrony and recovery upon its removal, linked to increased apoptosis.

Conclusions:

  • Circadian desynchrony is a significant risk factor for reduced sperm count in men.
  • Restoring circadian alignment may mitigate male reproductive damage.
  • Findings offer insights for preventing male reproductive health issues related to circadian disruption.
Keywords:
Pittsburg sleep quality indexchronobiology disorderscircadian desynchronyfertilitysemen qualityshift worksleep disorderssocial jetlagsperm countspermatogenesis

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