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Fed Macrophages Hit the Liver's Sweet Spot with IL-10
1KG Jebsen Center for Autoimmune Disorders, Department of Clinical Science, University of Bergen, Bergen, Norway; Integrated Cardio Metabolic Center, Department of Medicine, Karolinska Institutet, 141 57 Huddinge, Sweden.
Molecular Cell
|July 4, 2020
Abstract:
In this issue of Molecular Cell, Toda et al. (2020) show that postprandial elevation of LPS and insulin induce the production of IL-10 by adipose tissue macrophages. Hepatic gluconeogenesis is then inhibited synergistically by insulin and IL-10 to facilitate glucose clearance.

