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Updated: Dec 16, 2025

Spatiotemporal Subcellular Manipulation of the Microtubule Cytoskeleton in the Living Preimplantation Mouse Embryo using Photostatins
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Published on: November 30, 2021

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Pharmaceutical-Grade Rigosertib Is a Microtubule-Destabilizing Agent.

Marco Jost1, Yuwen Chen2, Luke A Gilbert3

  • 1Department of Cellular & Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA; Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA; Center for RNA Systems Biology, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94158, USA.

Molecular Cell
|July 4, 2020
PubMed
Summary

Rigosertib, an anti-cancer drug, kills cancer cells by destabilizing microtubules. This microtubule-destabilizing activity is inherent to rigosertib itself, not a contaminant, supporting its efficacy in clinical trials.

Keywords:
CRISPRaCRISPRichemical geneticsdrug mechanism of actiondrug target identificationmicrotubulesrigosertib

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