Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Non-enzymatic RNA Glycation is a Metabolic Sensor of Cellular Stress.

bioRxiv : the preprint server for biology·2026

Same author

Crip2 preserves hematopoietic stem and progenitor cell production through inhibition of Notch signals.

Development (Cambridge, England)·2026

Same author

Inherited resilience to clonal hematopoiesis by modifying stem cell RNA regulation.

Science (New York, N.Y.)·2026

Same author

N<sup>6</sup>-Methyladenosine: an RNA modification as a central regulator of cancer.

Nature reviews. Cancer·2025

Same author

pTα enhances mRNA translation and potentiates CAR T cells for solid tumor eradication.

Cell·2025

Same author

The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression.

Cancer cell·2025

Search research articles

Related Experiment Video

Updated: Dec 16, 2025

Modeling Chemotherapy Resistant Leukemia In Vitro

Modeling Chemotherapy Resistant Leukemia In Vitro

Published on: February 9, 2016

Rubbing Out Leukemia Stem Cells by Erasing the Eraser.

Yuanming Cheng¹, Hanzhi Luo¹, Michael G Kharas¹

¹Molecular Pharmacology Program, Center for Cell Engineering, Center for Stem Cell Biology, Center for Experimental Therapeutics, Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

|July 4, 2020

Summary

Two studies reveal that the ALKBH5 enzyme is crucial for sustaining acute myeloid leukemia (AML) stem cells. This finding highlights new epitranscriptome regulators involved in AML progression.

More Related Videos

Lentiviral-mediated Knockdown During Ex Vivo Erythropoiesis of Human Hematopoietic Stem Cells

Lentiviral-mediated Knockdown During Ex Vivo Erythropoiesis of Human Hematopoietic Stem Cells

Published on: July 16, 2011

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Published on: March 5, 2018

Related Experiment Videos

Last Updated: Dec 16, 2025

Modeling Chemotherapy Resistant Leukemia In Vitro

Modeling Chemotherapy Resistant Leukemia In Vitro

Published on: February 9, 2016

Lentiviral-mediated Knockdown During Ex Vivo Erythropoiesis of Human Hematopoietic Stem Cells

Lentiviral-mediated Knockdown During Ex Vivo Erythropoiesis of Human Hematopoietic Stem Cells

Published on: July 16, 2011

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Published on: March 5, 2018

Area of Science:

Molecular Biology
Cancer Research
Epigenetics

Background:

Acute myeloid leukemia (AML) is a heterogeneous cancer originating from hematopoietic stem cells.
The role of epitranscriptomic modifications in cancer stem cell maintenance is an emerging area of research.

Purpose of the Study:

To identify key regulators of the epitranscriptome in acute myeloid leukemia (AML) stem cells.
To elucidate the function of m6A demethylases in maintaining the stemness of myeloid leukemia cells.

Main Methods:

Investigated the role of m6A demethylase ALKBH5 in leukemia stem cell maintenance.
Utilized molecular and cellular biology techniques to assess ALKBH5 function in AML models.

Main Results:

Independent studies by Shen et al. and Wang et al. identified ALKBH5 as essential for myeloid leukemia stem cell survival.
ALKBH5 activity is critical for the maintenance of acute myeloid leukemia stem cells.

Conclusions:

The m6A demethylase ALKBH5 is a vital regulator for acute myeloid leukemia stem cells.
These findings expand the understanding of epitranscriptomic regulators in AML pathogenesis and suggest potential therapeutic targets.