Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

149
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
149
Obesity01:24

Obesity

1.0K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.0K
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

145
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
145
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

109
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
109
Types of Toxins01:36

Types of Toxins

3.0K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
3.0K
Regulation of Food Intake01:30

Regulation of Food Intake

2.1K
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
2.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development and characterization of a standardized adipogenesis assay for testing metabolism disrupting chemicals using human bone marrow derived mesenchymal stem cells.

NAM journal·2026
Same author

Di-tert-Butylphenol (2,4-DTBP) and its analogs disrupt thyroid hormone signaling via activation of retinoid X receptor α.

Environmental research·2026
Same author

Heritable changes in chromatin contacts associated with transgenerational susceptibility to diet-induced insulin dysregulation and obesity.

Nature communications·2026
Same author

Binding activities of bisphenol analogues toward TTR and TBG and their potential to disrupt thyroid hormone homeostasis.

Environmental pollution (Barking, Essex : 1987)·2026
Same author

The effect of cold exposure on energy expenditure of mice fed an obesogenic diet.

bioRxiv : the preprint server for biology·2025
Same author

Physiological Functions and Pathological Roles of PXR.

Journal of the Endocrine Society·2025

Related Experiment Video

Updated: Dec 16, 2025

Multidisciplinary Approach to Obesity Management: A Case Report
05:10

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

772

Agrochemicals and obesity.

Xiao-Min Ren1, Yun Kuo2, Bruce Blumberg3

  • 1Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China; Department of Developmental and Cell Biology, University of California, Irvine, CA, 92697-2300, USA.

Molecular and Cellular Endocrinology
|July 4, 2020
PubMed
Summary

Environmental agrochemical exposure is increasingly linked to the global obesity epidemic. This review examines evidence connecting these agricultural chemicals to obesity in humans and animals, exploring potential mechanisms.

Keywords:
AgrochemicalEDCEndocrine disrupting chemicalEpigeneticFungicideMicrobiomeObesogenPesticideTransgenerational

More Related Videos

An Acupoint Catgut-embedding Therapy for Treating Obesity
04:50

An Acupoint Catgut-embedding Therapy for Treating Obesity

Published on: April 4, 2025

985
Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents
09:10

Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents

Published on: November 1, 2019

11.3K

Related Experiment Videos

Last Updated: Dec 16, 2025

Multidisciplinary Approach to Obesity Management: A Case Report
05:10

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

772
An Acupoint Catgut-embedding Therapy for Treating Obesity
04:50

An Acupoint Catgut-embedding Therapy for Treating Obesity

Published on: April 4, 2025

985
Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents
09:10

Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents

Published on: November 1, 2019

11.3K

Area of Science:

  • Environmental Health
  • Toxicology
  • Epidemiology

Background:

  • Obesity is a global pandemic driven by lifestyle and genetics.
  • Environmental chemical exposure during development may increase obesity risk.
  • Agrochemicals are widely used and detected in humans, raising health concerns.

Purpose of the Study:

  • To review epidemiological and animal study evidence linking agrochemical exposure to obesity.
  • To explore potential biological mechanisms behind this association.

Main Methods:

  • Systematic review of human epidemiological studies.
  • Analysis of experimental animal studies on agrochemical exposure and obesity.
  • Literature synthesis of proposed mechanistic pathways.

Main Results:

  • Substantial evidence suggests a link between human agrochemical exposure and obesity.
  • Animal studies provide experimental support for this association.
  • Several potential mechanisms, including endocrine disruption and metabolic changes, are implicated.

Conclusions:

  • Agrochemical exposure is a potential contributing factor to the obesity epidemic.
  • Further research is needed to elucidate specific mechanisms and inform public health strategies.
  • Reducing environmental exposure to agrochemicals may be a relevant obesity prevention approach.