Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Thermosensation01:43

Thermosensation

32.8K
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
32.8K
Physical Methods for Controlling Microbial Growth: Temperature01:23

Physical Methods for Controlling Microbial Growth: Temperature

668
Heat is a widely used method to control microbial growth by targeting and denaturing cellular proteins, thereby killing or inactivating microbes. This method's effectiveness is quantified using parameters such as the thermal death point (TDP), thermal death time (TDT), and decimal reduction time (D value). TDP represents the lowest temperature at which all microorganisms in a liquid suspension are eliminated within 10 minutes, whereas TDT is the time necessary to achieve sterilization at a...
668
Decreased Body Temperature01:29

Decreased Body Temperature

771
A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...
771
Absorption of Radiation01:05

Absorption of Radiation

964
The rate of heat transfer by emitted radiation is described by the Stefan-Boltzmann law of radiation:
964
Mechanism of heat transfer01:19

Mechanism of heat transfer

1.6K
Understanding heat transfer mechanisms is essential for understanding how our bodies maintain balance in different environmental conditions. When the environment is thermoneutral, the body is in a state of balance, neither using nor releasing energy to maintain its core temperature. However, when the environment is not thermoneutral, the body employs four heat transfer mechanisms to maintain homeostasis: conduction, convection, evaporation, and radiation. These mechanisms facilitate heat...
1.6K
Body Temperature01:25

Body Temperature

3.5K
The body's temperature, measured in degrees, is determined by the balance between heat production and dissipation to the surrounding environment. For instance, if exercising vigorously, the body will produce more heat, causing sweat and dissipating that heat. Despite extreme environmental conditions and physical exertion, the human temperature-control system maintains a constant core body temperature (the temperature of deep tissues, which are the tissues located beneath the skin and other...
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

3D-printed long-acting implants for risperidone delivery using VAT photopolymerisation: a potential alternative for schizophrenia treatment.

International journal of pharmaceutics·2026
Same author

Preserving the gut microbiome: hydrogel-forming microneedle delivery of tetracycline reduces gut microbiome disruption compared to oral administration.

Drug delivery and translational research·2026
Same author

Ultrafast-dissolving voriconazole-cyclodextrin complex-based ocular microneedle patch: a novel approach for the treatment of fungal keratitis.

International journal of pharmaceutics·2026
Same author

Corrigendum to "Dynamics of insertion and extraction of hollow pyramidal microneedles: experiments and numerical modelling" [Int. J. Pharm. 682 (2025) 125989].

International journal of pharmaceutics·2026
Same author

Microneedle array platforms for drug delivery and biomarker sensing: From skin mechanics guided design to scalable manufacture for clinical utility.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same author

Transdermal ropivacaine delivery via hydrogel-forming microneedles: A pain-free alternative for local anaesthesia.

Drug delivery and translational research·2026

Related Experiment Video

Updated: Nov 4, 2025

Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods
09:23

Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods

Published on: October 10, 2025

867

Photothermal therapy.

Defu Zhi1, Ting Yang2, Justin O'Hagan3

  • 1Key Laboratory of Biotechnology and Bioresources Utilization of Ministry of Education, College of Life Science, Dalian Minzu University, Dalian, Liaoning 116600, China; School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|July 4, 2020
PubMed
Summary
This summary is machine-generated.

Microneedles (MNs) offer a minimally invasive, painless method for drug delivery, bypassing the skin barrier. This review highlights advances in using MNs with photodynamic therapy (PDT) and photothermal therapy (PTT) for improved disease treatment.

Keywords:
Controlled releaseMicroneedlesNano-materialsPhotodynamic therapyPhotothermal therapy

More Related Videos

Plasmonic Photothermal Cancer Therapy: Nanoparticle-embedded Tumor-tissue-mimicking Phantoms for Visualizing Photothermal Temperature Distribution
06:42

Plasmonic Photothermal Cancer Therapy: Nanoparticle-embedded Tumor-tissue-mimicking Phantoms for Visualizing Photothermal Temperature Distribution

Published on: May 9, 2025

792
Continuous-wave Thulium Laser for Heating Cultured Cells to Investigate Cellular Thermal Effects
09:49

Continuous-wave Thulium Laser for Heating Cultured Cells to Investigate Cellular Thermal Effects

Published on: June 30, 2017

8.0K

Related Experiment Videos

Last Updated: Nov 4, 2025

Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods
09:23

Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods

Published on: October 10, 2025

867
Plasmonic Photothermal Cancer Therapy: Nanoparticle-embedded Tumor-tissue-mimicking Phantoms for Visualizing Photothermal Temperature Distribution
06:42

Plasmonic Photothermal Cancer Therapy: Nanoparticle-embedded Tumor-tissue-mimicking Phantoms for Visualizing Photothermal Temperature Distribution

Published on: May 9, 2025

792
Continuous-wave Thulium Laser for Heating Cultured Cells to Investigate Cellular Thermal Effects
09:49

Continuous-wave Thulium Laser for Heating Cultured Cells to Investigate Cellular Thermal Effects

Published on: June 30, 2017

8.0K

Area of Science:

  • Biomedical Engineering
  • Drug Delivery Systems
  • Dermatology

Background:

  • Microneedles (MNs) provide a minimally invasive route for systemic drug administration by bypassing the stratum corneum.
  • MNs offer advantages such as simplicity, painlessness, and the ability to deliver diverse therapeutics, including macromolecules and DNA.
  • Combining MNs with therapies like photodynamic therapy (PDT) and photothermal therapy (PTT) shows promise for disease treatment.

Purpose of the Study:

  • To review recent advancements in microneedle (MN) technology for photodynamic therapy (PDT) and photothermal therapy (PTT).
  • To highlight the potential of MN-assisted phototherapies in improving disease diagnosis and treatment.

Main Methods:

  • Literature review of studies on microneedles combined with PDT and PTT.
  • Analysis of the advantages and applications of MN-assisted phototherapies.

Main Results:

  • Microneedles facilitate efficient transdermal delivery of therapeutics for PDT and PTT.
  • MN-assisted PDT and PTT offer enhanced selectivity, minimal invasiveness, and reduced side effects compared to conventional methods.
  • Various research groups and companies are actively exploring MN-assisted phototherapies for diverse applications.

Conclusions:

  • Microneedles represent a promising platform for enhancing the efficacy and safety of photodynamic and photothermal therapies.
  • Further research and development in MN-assisted PDT and PTT are expected to lead to significant clinical advancements.