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Impact of obstructive sleep apnea on left ventricular mass index in men with coronary artery disease

Zhihua Huang1,2, Ling Wang1, Yuanhui Liu1

  • 1Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine
|July 5, 2020
PubMed

Insights

Obstructive sleep apnea (OSA) severity increases left ventricular hypertrophy (LVH) risk in men with coronary artery disease (CAD). Nocturnal hypoxemia is a key factor, suggesting OSA management may reduce cardiovascular risk.

Area of Science:

  • Cardiology
  • Sleep Medicine
  • Internal Medicine

Background:

  • Left ventricular hypertrophy (LVH) is a significant risk factor for mortality in patients with coronary artery disease (CAD).
  • Obstructive sleep apnea (OSA) is common in patients with CAD and may contribute to cardiovascular complications.

Purpose of the Study:

  • To investigate the association between obstructive sleep apnea (OSA) severity and left ventricular mass index (LVMI) in men with established coronary artery disease (CAD).

Main Methods:

  • A cohort of 1,053 male patients with CAD underwent overnight portable monitoring to assess OSA.
  • Left ventricular mass index (LVMI) was measured using high-resolution echocardiography.
  • Univariate and multivariate regression analyses were performed to determine the relationship between OSA parameters and LVMI.

Main Results:

  • 40.4% of patients had moderate-to-severe OSA. LVH prevalence was 36.0%.
  • Increasing OSA severity correlated with higher mean LVMI (P < .001).
  • Severe OSA (respiratory event index ≥ 30 events/h) independently increased LVH risk by 2.30-fold. Minimum oxygen saturation < 70% was strongly associated with LVH (adjusted OR 3.62).

Conclusions:

  • OSA severity is linked to an increased likelihood of LVH in men with CAD, partly due to nocturnal intermittent hypoxemia.
  • Effective management of OSA in CAD patients may mitigate cardiovascular risk.
Abstract

Keywords:
coronary arteryhypoxemialeft ventricleoxygen saturationsleep apnea

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