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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
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[Innovations in systemic treatment of urothelial carcinoma]

Constance Thibault1, Marine Gross-Goupil2

  • 1Service d'oncologie médicale, Hôpital européen Georges-Pompidou, CHU de Paris, 20, rue Leblanc, 75015 Paris, France.

Bulletin Du Cancer
|July 5, 2020
PubMed

Insights

Recent advancements offer new hope for bladder cancer patients. Novel therapies like immune checkpoint inhibitors and targeted drugs are expanding treatment options for urothelial carcinoma.

Area of Science:

  • Uro-oncology
  • Medical oncology
  • Clinical research

Background:

  • Bladder cancer treatment options were limited until 2014.
  • Recent years have seen significant expansion in therapeutic classes.
  • Immune checkpoint inhibitors show survival benefits in metastatic settings.

Purpose of the Study:

  • To review current and future therapeutic studies for bladder cancer.
  • To highlight the emergence of new treatment modalities.
  • To provide an overview of advancements in urothelial carcinoma treatment.

Main Methods:

  • Review of clinical trials and therapeutic agent approvals.
  • Analysis of immune checkpoint inhibitors' efficacy.
  • Evaluation of targeted therapies and antibody-drug conjugates.

Main Results:

  • Immune checkpoint inhibitors demonstrate survival benefits in metastatic bladder cancer post-chemotherapy.
  • Targeted therapies, including FGFR inhibitors, show promise in early trials.
  • Antibody-drug conjugates are emerging as a new therapeutic class with positive early results.

Conclusions:

  • The treatment landscape for bladder cancer has rapidly evolved.
  • New therapeutic classes offer improved outcomes and options for patients.
  • Ongoing research is exploring these agents in earlier stages of urothelial carcinoma.
Keywords:
Anti-FGFRAnti-PARPAnticorps conjuguésCarcinome urothélialDrug-conjugateImmune checkpointImmunothérapieInhibiteursTargeted therapyThérapies cibléesUrothelial carcinomaantibodyde checkpointimmunologiqueinhibitors

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