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Autophagy in cardiovascular health and disease

Mahmoud Abdellatif1, Senka Ljubojevic-Holzer2, Frank Madeo3

  • 1Department of Cardiology, Medical University of Graz, Graz, Austria.

Progress in Molecular Biology and Translational Science
|July 5, 2020
PubMed

Insights

Autophagy, a cellular process vital for health, is crucial for cardiovascular function. Activating autophagy through diet, genetics, or drugs can combat cardiovascular diseases like heart failure and atherosclerosis.

Area of Science:

  • Cell Biology
  • Cardiovascular Science
  • Physiology

Background:

  • Autophagy is a fundamental cellular process responsible for maintaining homeostasis and quality control.
  • Dysregulation of autophagy in cardiac and vascular cells negatively impacts cardiovascular health and overall organismal well-being.

Purpose of the Study:

  • To review preclinical evidence on autophagy's role in cardiovascular health during homeostasis and disease.
  • To explore therapeutic strategies involving autophagy activation for cardiovascular disorders.

Main Methods:

  • Review of preclinical studies and scientific literature.
  • Analysis of evidence linking autophagy to cardiovascular function and disease pathogenesis.

Main Results:

  • Autophagy plays a critical role in maintaining cardiovascular health under normal physiological conditions.
  • Perturbations in autophagy flux contribute to the development of various cardiovascular pathologies.

Conclusions:

  • Autophagy activation presents a promising therapeutic avenue for managing cardiovascular diseases.
  • Dietary, genetic, and pharmaceutical interventions targeting autophagy can be leveraged to treat conditions such as atherosclerosis, heart failure, and cardiotoxicity.

Keywords:
AgingAutophagyCaloric restrictionCardiovascular diseaseHFpEFHFrEFIschemiaMimeticsMitophagyReperfusion

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