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Updated: Dec 16, 2025
Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
Published on: May 10, 2024
Low Eosinophil Percentages as a New Predictive Marker for Infusion Reactions Due to Trastuzumab
Masaya Takahashi1, Katsuyuki Takahashi2, Saya Matsumoto1
1Department of Pharmacy, Osaka City University Hospital, Osaka, Japan.
Background/Aim:
Infusion reactions (IRs) often occur with trastuzumab. Although premedication by non-steroidal anti-inflammatory drugs can be effective to a certain extent, IRs are still common and infrequently severe. Therefore, a predictive marker that can select patients requiring further prophylaxis is useful for appropriate prevention, but remains unclear.
Patients And Methods:
We conducted a retrospective analysis for 136 consecutive female inpatients aged 18 years and older who received 8 mg/kg of the initial trastuzumab administration for breast cancer with a 25-mg dose of rectal diclofenac before trastuzumab infusion between May 2007 and April 2019, in order to assess IRs.
Results:
Overall, 57 patients were eligible for inclusion in the study. IRs were observed in 17.5% (10/57) of the patients. Univariate analysis showed that patients with a low eosinophil percentage (≤2%) were associated with IRs (p=0.016).
Conclusion:
A low eosinophil percentage can be a useful new predictive marker for trastuzumab-induced IRs in patients with breast cancer.
