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A Single Institution's Experience of Definitive Radiotherapy Using Volumetric-modulated Arc Therapy for
Katsumaro Kubo1, Yuji Murakami2, Nobuki Imano2
1Department of Radiation Oncology, Hiroshima University Hospital, Hiroshima, Japan maro1987@hotmail.co.jp.
Background/Aim:
The present study aimed to analyze the treatment outcome after definitive radiotherapy (dRT) using volumetric-modulated arc therapy (VMAT) in patients with hypopharyngeal cancer (HPC), including an examination of late toxicities.
Patients And Methods:
A total of 62 patients with HPC, who underwent dRT using VMAT, were analyzed. Overall survival (OS), progression-free survival (PFS), laryngoesophageal dysfunction-free survival (LEDFS), and locoregional control (LRC) were calculated.
Results:
The median follow-up period was 49 months. The 3- and 5-year OS, PFS, LEDFS, and LRC rates were 77% and 60%, 61% and 56%, 66% and 53%, and both 79%, respectively. Regarding late toxicities, 11 (17.7%) patients developed grade ≥2 late toxicity. Grade 3 dysphagia was observed in 4 (6.5%) patients, and grade 2 xerostomia in 6 (9.7%).
Conclusion:
VMAT was an effective treatment for HPC, with a low incidence of late toxicities.
