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Sleeve Gastrectomy in Mice using Surgical Clips

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Surgery-Induced Weight Loss and Changes in Hormonally Active Fibroblast Growth Factors: a Systematic Review and

Ali Hosseinzadeh¹, Leonardo Roever², Shahab Alizadeh³

¹School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran.

Obesity Surgery

|July 5, 2020

Abstract:

This systematic review and meta-analysis was performed to investigate the possible changes of FGF-19 and FGF-21 after bariatric surgery (BS). Electronic databases including PubMed and Scopus were systematically searched up to February 2020 to identify pertinent studies. A total of 25 different studies were included. The overall pooled analysis identified that BS caused a significant increase in FGF-19, but had no significant effect on FGF-21. For FGF-19, this finding was supported in the subgroup analyses. For FGF-21, Roux-en-Y gastric bypass (RYGB) surgery significantly increased FGF-21 levels, whereas, in studies with follow-up duration ≥ 1 year, FGF-21 levels decreased significantly. BS reduces circulating concentration of FGF-19, but might increase FGF-21 after RYGB or decrease FGF-21 after ≥ 1 year.

Keywords:

Bariatric surgery FGF-19 FGF-21 Fibroblast growth factor Obesity Weight loss

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