Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Horse pill ("bute") hemorrhage.

M L Cohen1, R H Ming, H K Gogel

  • 1Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque 87131.

Journal of Clinical Gastroenterology
|April 1, 1988
PubMed
Summary

Phenylbutazone (PBZ), an NSAID, is widely used in horses but poses risks for humans. A horse handler developed severe gastric bleeding from self-medicating with horse pills for toothache, highlighting potential dangers.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

LOH and mutation analysis of CDKN2 in primary human ovarian cancers.

International journal of cancer·1995
Same author

Peptidyl alpha-ketoheterocyclic inhibitors of human neutrophil elastase. 3. In vitro and in vivo potency of a series of peptidyl alpha-ketobenzoxazoles.

Journal of medicinal chemistry·1995
Same author

Telephone use and costs in a group subspecialty practice.

The Western journal of medicine·1995
Same author

Myositis and fasciitis associated with group A beta hemolytic streptococcal infections: development of a rabbit model.

The Journal of laboratory and clinical medicine·1995
Same author

Esophago-airway fistula in AIDS.

The Annals of thoracic surgery·1995
Same author

Lesions of the central nucleus of the amygdala block conditioned excitation, but not conditioned inhibition of fear as measured with the fear-potentiated startle effect.

Behavioral neuroscience·1995

Area of Science:

  • Veterinary Medicine
  • Human Pharmacology
  • Gastroenterology

Background:

  • Phenylbutazone (PBZ) is a potent nonsteroidal anti-inflammatory drug (NSAID) with significant adverse effects.
  • Despite risks, PBZ remains prevalent in equine medicine due to its efficacy.
  • Accessibility of PBZ for horse handlers raises concerns about unsupervised human consumption.

Observation:

  • A 33-year-old male racehorse track worker self-administered PBZ horse pills for a persistent toothache.
  • The individual experienced a severe gastrointestinal hemorrhage.
  • The hemorrhage was directly linked to a gastric ulcer.

Findings:

  • The case demonstrates a direct link between non-prescribed human ingestion of equine PBZ and serious gastric complications.

Related Experiment Videos

  • Gastric ulceration and hemorrhage are significant risks associated with Phenylbutazone use.
  • Unsupervised use of veterinary drugs by laypersons can lead to severe health consequences.

    • Implications:

    • Physicians should consider equine Phenylbutazone exposure in patients presenting with upper GI symptoms and gastric injury, particularly those with equine connections.
    • This case underscores the importance of regulating access to and educating individuals about the risks of using veterinary drugs for human ailments.
    • Enhanced awareness and caution are needed regarding the potential for misuse of animal medications in human populations.