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Nutrition Interventions Associated With Favorable Growth in Infants With Congenital Diaphragmatic Hernia
Jennifer R Bathgate1, Diane Rigassio Radler2, Rena Zelig2
1School of Health Professions, Department of Clinical and Preventive, Lurie Children's Hospital, Nutrition Sciences, Rutgers University, Chicago, Illinois, USA.
Insights
Early nutrition support, including higher calorie and protein intake via parenteral nutrition, may improve growth and neurological development in infants with congenital diaphragmatic hernia (CDH). This approach could enhance outcomes for these vulnerable patients.
Area of Science:
- Pediatric Surgery
- Neonatal Nutrition
- Critical Care Medicine
Background:
- Congenital diaphragmatic hernia (CDH) survivors frequently experience nutritional challenges.
- Infants with CDH often exhibit poor growth despite standard enteral feeding and reflux management.
- Optimizing nutrition is crucial for improving outcomes in CDH patients.
Purpose of the Study:
- To identify effective nutrition interventions for promoting favorable growth in infants with CDH.
- To evaluate the impact of specific nutritional strategies on growth and potential neurological development.
Main Methods:
- Conducted a literature review to synthesize existing research on nutrition interventions for CDH survivors.
- Analyzed studies focusing on early nutrition support, including enteral and parenteral nutrition strategies.
- Examined data on calorie and protein intake levels associated with improved growth outcomes.
Main Results:
- Early nutrition support, particularly supplemental parenteral nutrition, shows promise for improving growth.
- Higher nutritional provisions (≥125 kcal/kg/d and ≥2.3 g/kg/d protein) were associated with positive growth impacts.
- These enhanced nutritional strategies exceed standard dietary reference intakes for infants.
Conclusions:
- Aggressive early nutrition support, including high-calorie, high-protein parenteral nutrition, may be beneficial for CDH infants.
- Improved growth achieved through these interventions could positively influence long-term outcomes, including neurological development.
- Further research is warranted to establish optimal nutrition protocols for congenital diaphragmatic hernia management.
Abstract:
Nutrition complications are common in survivors of congenital diaphragmatic hernia (CDH). Infants diagnosed with CDH may demonstrate poor growth despite receiving enteral tube feedings and gastroesophageal reflux treatment. This literature review was conducted to determine nutrition interventions resulting in favorable growth, which may improve outcomes in these infants. Results indicate that early nutrition support, including supplemental parenteral nutrition with provisions of ≥125 kcal/kg/d and ≥2.3 g/kg/d protein (which are higher than dietary reference intakes for infants), may have a positive impact on growth, potentially impacting neurological development.
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