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Cutaneous undifferentiated pleomorphic sarcoma is a pleomorphic dermal sarcoma.

Philip R Cohen1

  • 1San Diego Family Dermatology, National City, CA Touro University California College of Osteopathic Medicine, Vallejo, CA Scripps Family Medicine Residency, Scripps Mercy Hospital Chula Vista, Chula Vista, CA Family Medicine Residency, Family Health Centers of San Diego, San Diego, CA. mitehead@gmail.com.

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Pleomorphic dermal sarcoma is a rare skin cancer in elderly individuals, often mistaken for atypical fibroxanthoma. Recognizing its distinct aggressive features is key for effective treatment and improved patient outcomes.

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Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Pleomorphic dermal sarcoma (PDS) is a rare cutaneous soft tissue sarcoma.
  • It often presents in elderly individuals on sun-exposed skin.
  • PDS shares similarities with atypical fibroxanthoma (AFX).

Observation:

  • A case of PDS in a woman is presented.
  • The sarcoma appeared as a rapidly growing, ulcerated red nodule on the face.
  • Imaging preceded surgical extirpation.

Findings:

  • Adverse histologic features differentiate PDS from AFX, indicating a more aggressive behavior.
  • PDS can lead to local recurrence and metastasis.
  • The patient underwent wide local excision and radiotherapy with no recurrence at one-year follow-up.

Implications:

  • Accurate classification of PDS is crucial for appropriate management.
  • The term PDS is preferred for undifferentiated soft tissue sarcomas of cutaneous origin.
  • Early recognition and treatment of PDS can lead to favorable outcomes.