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Gray matter volume differences between lower, average, and higher pain resilience subgroups.

Fenghua Li1, Todd Jackson1,2

  • 1Key Laboratory of Cognition & Personality Southwest University, Chongqing, China.

Psychophysiology
|July 5, 2020
PubMed
Summary
This summary is machine-generated.

Lower pain resilience is linked to greater gray matter volume in pain processing areas and reduced volume in resilience regions. These brain structure differences show complex, nonlinear associations with pain resilience.

Keywords:
gray matter volumepainresiliencestructural MRIvoxel-based morphometry

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Area of Science:

  • Neuroscience
  • Psychology

Background:

  • Resilience, the ability to function well under adversity, aids adaptation to stressors like pain.
  • Previous resilience research often used questionnaires or task performance, which may not fully capture complex associations with brain structure.
  • Extreme subgroup comparisons limit understanding of nonlinear relationships between resilience and brain matter volume.

Purpose of the Study:

  • To investigate the relationship between pain resilience levels and gray matter volume (GMV).
  • To explore differences in cognitive task performance across resilience subgroups.
  • To identify potential nonlinear associations between resilience and brain structure.

Main Methods:

  • Identified high (HPR), moderate (MPR), and low (LPR) pain resilience subgroups based on questionnaire and behavioral data.
  • Assessed behavioral responses using a novel numerical interference task (NIT) during pain.
  • Analyzed gray matter volume (GMV) differences using voxel-based morphology.

Main Results:

  • The LPR subgroup responded slower to pain-associated NIT trials compared to MPR and HPR subgroups.
  • LPR subgroups exhibited greater GMV in the left postcentral gyrus compared to MPR and HPR.
  • MPR and LPR subgroups showed larger GMV in the right inferior temporal gyrus than HPR subgroups, with nonlinear associations observed in other regions.

Conclusions:

  • Lower pain resilience is associated with greater GMV in pain processing regions and reduced GMV in regions linked to resilience.
  • Brain structure differences related to resilience are complex and exhibit nonlinear patterns.
  • Findings highlight the neuroanatomical correlates of pain resilience, offering insights into adaptation mechanisms.