Related Experiment Video
Updated: Dec 16, 2025
Method of Studying Palatal Fusion using Static Organ Culture
Published on: September 19, 2015
A systematic approach on the frequency of cleft lip/palate in pediatric patients with leukemia
D A Prodan1, S Bran1, C Dinu1
1Department of Maxillofacial Surgery and Implantology, University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca, Romania.
Insights
This study found limited evidence linking pediatric cleft lip/palate (CL/P) with leukemia. Further research with larger patient groups is necessary to confirm any association between CL/P and leukemia.
Area of Science:
- Pediatric Hematology
- Craniofacial Anomalies
- Oncology
Background:
- Cleft lip/palate (CL/P) are common congenital anomalies.
- The potential association between CL/P and childhood leukemia requires further investigation.
Purpose of the Study:
- To systematically review and analyze the existing literature on the frequency of leukemia in pediatric patients with cleft lip/palate.
Main Methods:
- A systematic literature search was conducted across PubMed, Web of Science, and Cochrane databases.
- Keywords included various terms for cleft lip/palate and leukemia types.
- Studies published up to March 2020 reporting an association were included.
Main Results:
- Five studies (2 case-control, 3 cohort) met the inclusion criteria.
- Case-control studies identified 9 CL/P cases among 445 leukemia patients (ALL/AML).
- Cohort studies found 6 CL/P cases among 10 ALL patients.
Conclusions:
- The current literature provides limited evidence for an association between CL/P and leukemia in pediatric patients.
- Larger cohort studies are essential to establish a definitive correlation.
Purpose:
The purpose of this study was to reveal the frequency between cleft lip/palate and leukemia in pediatric patients by a systematic analysis of the current literature.
Materials And Methods:
Electronic search on three database (PubMed, Web of Science, Cochrane) was carried out using the following keywords: cleft lip, cleft palate, facial cleft, oral cleft, orofacial cleft, leukemia, acute myeloid leukemia, acute lymphocytic leukemia, lymphoma. Studies published until March 2020 reporting an association between leukemia and cleft lip/palate (CL/P) were included in our research.
Results:
Five articles (2 case-controls, 3 cohorts), met the inclusion criteria. Case-control studies involved 268 patients with acute lymphocytic leukemia (ALL) and 177 patients with acute myeloid leukemia (AML), of which 9 patients had CL/P. The cohorts studies involved 10 patients with ALL, of which 6 patients with CL/P, 2 patients with cleft palate and 1 patient with cleft lip and palate.
Conclusion:
This research was able to indicate a limited evidence of the association between CL/P and leukemia. In order to draw a clear conclusion, studies with larger cohorts are needed to establish this correlation.
More Related Videos
08:31Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia
Published on: October 17, 2025
09:57Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia
Published on: March 5, 2018
Related Concept Videos
01:22Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
01:26Pharmacokinetics in Pediatric Patients: Drug Excretion