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Glaucoma: Overview01:25

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
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Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
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[Uveitic glaucoma in Behçet's disease: When everything gets complicated].

K Belkhadir1, N Boutimzine1, S Tachfouti1

  • 1Ophthalmology unit A, hôpital des spécialités, faculty of medicine and pharmacy, university Mohammed V, Rabat, Maroc.

Journal Francais D'Ophtalmologie
|July 6, 2020
PubMed
Summary

Glaucoma is a serious complication in Behçet

Keywords:
Behçet's diseaseGlaucome secondaireGlaucome uvéitiqueMaladie de BehçetSecondary glaucomaUveitic glaucomaUveitisUvéite

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Area of Science:

  • Ophthalmology
  • Rheumatology
  • Systemic Inflammatory Diseases

Background:

  • Behçet's disease is a systemic inflammatory disorder of unknown cause.
  • Ocular manifestations are common, with uveitis being the most frequent.
  • Elevated intraocular pressure (glaucoma) is an uncommon but significant complication.

Purpose of the Study:

  • To identify predictive factors for glaucoma development in patients with Behçet's disease.
  • To analyze the characteristics and management of glaucoma in this patient cohort.

Main Methods:

  • Retrospective chart review of patients hospitalized for Behçet's disease over 8 years.
  • Analysis of demographic data, ocular findings, and treatment outcomes.
  • Statistical analysis including univariate and multivariate methods to identify risk factors.

Main Results:

  • Glaucoma was diagnosed in 22% of Behçet's disease patients (11/50).
  • Independent risk factors for glaucoma included low initial visual acuity, retinal vasculitis, and a high number of disease recurrences.
  • Associated glaucoma types included primary open-angle glaucoma and secondary glaucoma due to synechiae.

Conclusions:

  • Glaucoma is a challenging complication in Behçet's disease management.
  • Vigilance for glaucoma is crucial in patients with severe posterior segment inflammation.
  • Effective management strategies are needed to prevent vision loss from glaucoma in Behçet's disease.