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Updated: Dec 16, 2025

Author Spotlight: Unraveling the Interplay Between Trichoderma stromaticum and the Mammalian Immune System
Published on: October 20, 2023
Fungal Melanin Rewires Macrophage Metabolism
Nicolas Papon1, Jean-Pierre Gangneux2, Yves Delneste3
1Host-Pathogen Interaction Study Group (GEIHP) EA3142, Université d'Angers and Université de Brest, Angers, France; Interactions Cellulaires et Applications Thérapeutiques (ICAT), Structure Féderative de Recherche (SFR) 4208, Université d'Angers, Angers, France.
Abstract:
Aspergillus fumigatus is a deadly fungal pathogen in immunocompromised patients. A report by Gonçalves et al. reveals that melanin, a secondary metabolite present at the surface of infecting fungal spores, induces glycolysis in macrophages to promote inflammatory responses. This opens a window for the development of innovative host-directed antifungal therapies.
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