Nanovehicles for co-delivery of anticancer agents

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Mahdi Zeinali1, Soheil Abbaspour-Ravasjani2, Marjan Ghorbani3

  • 1Student Research Committee and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran; Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Drug Discovery Today
|July 6, 2020
PubMed

Insights

Combining drugs or gene therapies using nanovehicles offers a promising strategy for enhanced cancer treatment. This approach improves drug delivery, boosts therapeutic effects, and minimizes resistance and side effects.

Area of Science:

  • Oncology
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Cancer treatment faces challenges with single-agent therapies.
  • Multidrug resistance and side effects limit current treatments.
  • Targeting multiple pathways is crucial for effective cancer therapy.

Purpose of the Study:

  • To review the advantages of nano-based co-delivery systems in cancer therapy.
  • To summarize nanovehicle types and preparation methods for co-delivery.
  • To discuss recent studies on co-delivery applications in cancer treatment.

Main Methods:

  • Review of existing literature on nanovehicle-based co-delivery systems.
  • Analysis of different nanocarrier types and their synthesis.
  • Compilation and discussion of recent research findings in cancer co-therapy.

Main Results:

  • Nanovehicles enhance drug uptake, biodistribution, and tumor accumulation.
  • Co-delivery of multiple agents increases therapeutic efficacy.
  • Simultaneous delivery reduces side effects and combats multidrug resistance.

Conclusions:

  • Nano-based co-delivery represents a significant advancement in cancer treatment strategies.
  • Optimized nanovehicles can improve the precision and effectiveness of combination cancer therapies.
  • Further research into co-delivery systems holds potential for overcoming current therapeutic limitations.

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