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Long non-coding RNA TINCR as potential biomarker and therapeutic target for cancer

Uttam Sharma1, Tushar Singh Barwal1, Akshay Malhotra2

  • 1Department of Zoology, Central University of Punjab, Bathinda, Punjab, India.

Life Sciences
|July 6, 2020
PubMed

Insights

Long non-coding RNAs (lncRNAs) like TINCR are crucial in cancer. TINCR shows potential as a biomarker for early detection and personalized cancer therapy, impacting tumor progression.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cancer remains a leading global cause of death despite advances in diagnostics and therapeutics.
  • Novel biomarkers and molecular targets are essential for improving cancer patient outcomes.
  • Long non-coding RNAs (lncRNAs) are implicated in tumorigenesis and offer potential as cancer biomarkers and therapeutic targets.

Purpose of the Study:

  • To discuss the regulatory functions and mechanisms of TINCR in cancer.
  • To explore TINCR's role in targeting signaling pathways relevant to cancer hallmarks.
  • To highlight TINCR's potential clinical utility in cancer management.

Main Methods:

  • Literature review of recent discoveries on TINCR and cancer.
  • Analysis of TINCR's impact on cancer-associated signaling pathways.
  • Evaluation of studies on TINCR's clinical applications.

Main Results:

  • Tissue differentiation-inducing non-protein coding RNA (TINCR) is dysregulated in various cancers.
  • TINCR influences tumor development and progression by targeting key molecules in signaling pathways.
  • TINCR plays a role in cancer hallmarks and pathogenesis.

Conclusions:

  • TINCR is a significant lncRNA with regulatory functions in cancer pathogenesis.
  • TINCR holds promise as a biomarker for early cancer detection and risk stratification.
  • TINCR may serve as a molecular target for personalized cancer therapies.
Keywords:
BiomarkerCancerLncRNALong non-coding RNATINCRTissue differentiation-inducing non-protein coding RNA

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