Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gross Anatomy of Skeletal Muscles01:12

Gross Anatomy of Skeletal Muscles

18.4K
The connective tissues play a significant role in arranging the muscle fibers into a hierarchical structure that forms a complete muscle. Consider a muscle like the bicep brachii, commonly called the bicep. This muscle comprises thousands of muscle fibers enclosed by a protective layer of connective tissue called the endomysium. The endomysium is primarily composed of reticular fibers, a type of thin collagen fiber. It allows the exchange of nutrients and waste products at the fiber level,...
18.4K
Introduction to the Skeletal System01:20

Introduction to the Skeletal System

8.5K
The skeletal system is the central framework of the body, consisting of different connective tissues: bones, cartilage, tendons, and ligaments.
Components of the Skeletal System
Bone, or osseous tissue, is a hard connective tissue that forms an internal support structure for the human body. Bones shield vulnerable organs and soft tissue from external forces. For example, the vertebral bones protect and support the spinal cord.
Cartilage, a semi-rigid connective tissue found in regions such as...
8.5K
Bone as Supporting Connective Tissue01:23

Bone as Supporting Connective Tissue

6.1K
Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts—...
6.1K
Skeletal Muscle Anatomy00:55

Skeletal Muscle Anatomy

92.3K
Skeletal muscle is the most abundant type of muscle in the body. Tendons are the connective tissue that attaches skeletal muscle to bones. Skeletal muscles pull on tendons, which in turn pull on bones to carry out voluntary movements.
92.3K
Growth of Cartilage and Bone Tissue01:27

Growth of Cartilage and Bone Tissue

3.8K
Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
3.8K
The Bone Matrix01:18

The Bone Matrix

5.3K
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
5.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-Time Ferroelectric Domain Wall Dynamics During Electric Poling and Depoling.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Integrated hyperspectral-multispectral mapping of shear-associated hydrothermal alteration and gold mineralization validated by geochemical and isotopic data, southern Arabian Shield.

Scientific reports·2026
Same author

In situ imaging of domain walls in ferroelectric single crystals by instant polarized light microscopy.

The Review of scientific instruments·2026
Same author

High-speed polarization imaging for <i>in situ</i> quality assessment in the fiber spinning process.

Applied optics·2025
Same author

Investigation of Structural and Spectral Peculiarities of <i>Fusarium</i> sp. Indicator Pigment Bostrycoidin.

Molecules (Basel, Switzerland)·2024
Same author

Optimal Design of a Sensor Network for Guided Wave-Based Structural Health Monitoring Using Acoustically Coupled Optical Fibers.

Sensors (Basel, Switzerland)·2024

Related Experiment Video

Updated: Dec 16, 2025

Author Spotlight: Advancing Tendon Tissue Engineering with 3D Organoid Models
03:35

Author Spotlight: Advancing Tendon Tissue Engineering with 3D Organoid Models

Published on: June 21, 2024

2.1K

A structural-based computational model of tendon-bone insertion tissues.

Sergey Kuznetsov1, Mark Pankow1, Kara Peters1

  • 1North Carolina State University, United States of America.

Mathematical Biosciences
|July 6, 2020
PubMed
Summary
This summary is machine-generated.

This study models tendon-to-bone insertion, revealing that spatial grading of material properties significantly reduces peak stresses. This computational model aids in understanding tissue remodeling and developing orthopedic implants.

Keywords:
Biaxial mechanical testingConstitutive modelFiber dispersionFunctionally graded materialsGraded microstructureShape optimization

More Related Videos

Author Spotlight: Unraveling the Mechanobiology of Tendon Impingement &#8211; A Multiaxial Murine Hind Limb Explant Model
08:19

Author Spotlight: Unraveling the Mechanobiology of Tendon Impingement – A Multiaxial Murine Hind Limb Explant Model

Published on: December 8, 2023

1.4K
Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms
08:32

Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms

Published on: March 22, 2024

1.5K

Related Experiment Videos

Last Updated: Dec 16, 2025

Author Spotlight: Advancing Tendon Tissue Engineering with 3D Organoid Models
03:35

Author Spotlight: Advancing Tendon Tissue Engineering with 3D Organoid Models

Published on: June 21, 2024

2.1K
Author Spotlight: Unraveling the Mechanobiology of Tendon Impingement &#8211; A Multiaxial Murine Hind Limb Explant Model
08:19

Author Spotlight: Unraveling the Mechanobiology of Tendon Impingement – A Multiaxial Murine Hind Limb Explant Model

Published on: December 8, 2023

1.4K
Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms
08:32

Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms

Published on: March 22, 2024

1.5K

Area of Science:

  • Biomechanics
  • Biomaterials Science
  • Computational Modeling

Background:

  • Tendon-to-bone insertion facilitates gradual tissue transition, crucial for managing stress concentrations.
  • Macroscopic mechanical properties depend on internal structures like collagen fiber orientation and mineralization levels.

Purpose of the Study:

  • To develop a structural model of tendon-to-bone insertion incorporating fiber orientation, dispersion, and mineralization.
  • To investigate the impact of spatial material property grading on stress distribution.
  • To optimize tissue model geometry for in-vivo tissue remodeling mimicry.

Main Methods:

  • Developed a structural-based computational model of tendon-to-bone insertion.
  • Utilized a Python script for spatial grading of material properties within the transition zone.
  • Employed linear interpolation for material property transitions and compared with piecewise models.
  • Optimized model geometry by minimizing peak stress.

Main Results:

  • Spatially graded material properties resulted in smoother stress distributions compared to piecewise models.
  • Significantly reduced peak stress concentrations at the tendon-bone junction.
  • In-silico models were validated against in-situ biaxial mechanical testing data.

Conclusions:

  • Computational models accurately predict tendon-to-bone insertion behavior, aiding in understanding tissue remodeling.
  • Optimized models can inform the design of improved orthopedic implants.