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Updated: Dec 16, 2025

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
TH17/Treg imbalance and IL-17A increase after severe aneurysmal subarachnoid hemorrhage
Leandro Moraes1, Natalia Trias2, Andreina Brugnini2
1Cátedra de Medicina Intensiva, Hospital de Clínicas, Facultad de Medicina, Universidad de la República, Av Italia s/n, 11300 Montevideo, Uruguay; Laboratorio de Citometria y Biologia Molecular, Departamento Básico de Medicina, Hospital de Clínicas, Facultad de Medicina, Universidad de la República, Av Italia s/n, 11300 Montevideo, Uruguay.
None:
To evaluate cerebrospinal fluid (CSF) and peripheral blood (PB) Treg, TH17 cells, TH1, TH2 and related cytokines in the acute phase of aSAH we assessed TH17, TH1, TH2, T regulatory cells and neutrophils in 39 aneurysmal subarachnoid hemorrhage (aSAH) patients and 56 controls. PB TH17 cells and TH17/Treg ratio were higher in CSF and PB of aSAH patients. Serum and CSF IL-17A levels were increased in aSAH. Serum IL-17A levels were associated with vasospasm and ICU mortality. Study results support the role of TH17/IL17 axis in aSAH pathogenesis, turning it into a potential clinical biomarker and a novel target for research.
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