Developing a new chemosensor targeting zinc ion based on two types of quinoline platform

A chemosensor DQ (2-(2-(quinolin-2-yl)hydrazinyl)-N-(quinolin-8-yl)acetamide), based on two quinoline moieties, has been synthesized. DQ could detect zinc ion through fluorescence turn-on in aqueous media. Limit of detection was calculated as 0.07 μM, far lower than the standard of WHO for zinc ion. The practicality of DQ was demonstrated via the successful results of reusability with EDTA, easy detection on the test strip, and precise quantification in real water samples. Additionally, sensor DQ could be applied to bioimaging of zinc ion in zebrafish. Sensing process of zinc ion by DQ was studied through fluorescence and UV-Vis spectroscopy, ¹H NMR titration, and ESI-mass spectrometry.