Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

13.8K
Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
13.8K
Conserved Binding Sites01:49

Conserved Binding Sites

4.9K
Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally...
4.9K
Conservation of Protein Domains02:26

Conservation of Protein Domains

3.8K
3.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multifunctional Hyaluronic Acid Releasing Hydrogel Film With Nano/Micro Wrinkles: Thin Acne Patch for Localized Therapeutics.

Macromolecular bioscience·2026
Same author

Identifying the net information flow direction in mutually coupled non-identical chaotic oscillators.

Chaos (Woodbury, N.Y.)·2026
Same author

An integrated multi-criteria decision-making approach for evaluating healthcare service quality: a provider-centric assessment.

Journal of health organization and management·2025
Same author

Human sclerostin-inspired short peptides reverse osteoporosis and suppress joint degeneration in osteoarthritis via opposing Wnt pathways.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2025
Same author

Two-dimensional materials can inhibit Aβ fibrillation in Alzheimer's disease.

Physical chemistry chemical physics : PCCP·2025
Same author

Development of a new software for pore measurements in foraminifera and the constraints of pore proxy under high oxygen conditions.

Scientific reports·2025
Same journal

An interpretable framework for cancer drug response prediction using integrated drug and multi-omics data with a hybrid Bi-LSTM-GRU network.

Computational biology and chemistry·2026
Same journal

SegMWB: A lightweight deep learning framework for microscopic image classification.

Computational biology and chemistry·2026
Same journal

Protein dynamic simulations: From early inception to clinical translation over half a century.

Computational biology and chemistry·2026
Same journal

Integrated omics and virtual screening predict Tabularin as a dual inhibitor of the prognostic microRNAs mir-19a and mir-32 in colorectal cancer.

Computational biology and chemistry·2026
Same journal

In silico characterization of acetyl-CoA carboxylase from Staphylococcus aureus and Escherichia coli: A comparative analysis.

Computational biology and chemistry·2026
Same journal

An optimized cascaded transformer with progressive attention for lung and colon cancer diagnosis from histopathological images.

Computational biology and chemistry·2026
See all related articles

Related Experiment Video

Updated: Dec 16, 2025

An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

3.8K

Identifying essential proteins using modified-monkey algorithm (MMA).

Anjan Kumar Payra1, Anupam Ghosh2

  • 1Department of Computer Science & Engineering, Dr. Sudhir Chandra Sur Degree Engineering College, 540, Dum Dum Road, Near Dum Dum Jn. Station, Surermath, Kolkata, 700074, India.

Computational Biology and Chemistry
|July 6, 2020
PubMed
Summary
This summary is machine-generated.

A new modified-Monkey algorithm (MMA) effectively identifies essential proteins in protein-protein interaction networks. This computational approach shows higher success rates than existing methods for essential protein prediction.

Keywords:
CentralityClassifierComplex density scoreHybrid weighted approach

More Related Videos

Identification of Functional Protein Regions Through Chimeric Protein Construction
11:39

Identification of Functional Protein Regions Through Chimeric Protein Construction

Published on: January 8, 2019

10.8K
Identification of Antibacterial Immunity Proteins in Escherichia coli using MALDI-TOF-TOF-MS/MS and Top-Down Proteomic Analysis
09:26

Identification of Antibacterial Immunity Proteins in Escherichia coli using MALDI-TOF-TOF-MS/MS and Top-Down Proteomic Analysis

Published on: May 23, 2021

3.5K

Related Experiment Videos

Last Updated: Dec 16, 2025

An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

3.8K
Identification of Functional Protein Regions Through Chimeric Protein Construction
11:39

Identification of Functional Protein Regions Through Chimeric Protein Construction

Published on: January 8, 2019

10.8K
Identification of Antibacterial Immunity Proteins in Escherichia coli using MALDI-TOF-TOF-MS/MS and Top-Down Proteomic Analysis
09:26

Identification of Antibacterial Immunity Proteins in Escherichia coli using MALDI-TOF-TOF-MS/MS and Top-Down Proteomic Analysis

Published on: May 23, 2021

3.5K

Area of Science:

  • Computational Biology
  • Bioinformatics
  • Systems Biology

Background:

  • Proteins are crucial macromolecules for cellular life, with essential proteins regulating molecular mechanisms.
  • Understanding protein-protein interaction networks (PPINs) is vital for cellular function and drug discovery.
  • Existing computational algorithms for essential protein identification require further optimization.

Purpose of the Study:

  • To propose a novel computational algorithm, the modified-Monkey algorithm (MMA), for identifying essential proteins.
  • To evaluate the efficacy of MMA in predicting essential proteins within protein-protein interaction networks (PPINs).

Main Methods:

  • Developed the modified-Monkey algorithm (MMA) inspired by monkey traversal behaviors (climb, watch-jump, somersault).
  • Applied MMA to protein-protein interaction networks (PPINs) to identify essential proteins.
  • Compared MMA's performance against established methods like Eigenvector Centrality (EC), Betweenness Centrality (BC), and Network Centrality (NC).

Main Results:

  • The modified-Monkey algorithm (MMA) demonstrated superior performance in identifying essential proteins.
  • MMA achieved higher success rates compared to existing state-of-the-art essential protein prediction methodologies.
  • The algorithm's traversal processes effectively mapped onto PPINs for accurate essential protein identification.

Conclusions:

  • The modified-Monkey algorithm (MMA) is a promising computational tool for essential protein identification in PPINs.
  • MMA offers an optimized approach for understanding molecular mechanisms and aiding drug discovery.
  • Further research can explore MMA's application in diverse biological networks.