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Inhibition of Nb2 T-lymphoma cell growth by transforming growth factor-beta
E J Rayhel1, D A Prentice, P S Tabor
1Department of Life Sciences, Indiana State University, Terre Haute.
The Biochemical Journal
|July 1, 1988
Abstract:
Transforming growth factor-beta (TGF-beta) inhibits proliferation of Nb2 cells, a rat T lymphoma, in response to lactogens and interleukin-2. Prostaglandins may play an important role in the pathway through which TGF-beta exerts its inhibitory actions, because prostaglandin E2 also inhibits proliferation of Nb2 cells, and indomethacin, an inhibitor of prostaglandin synthesis, reverses the inhibitory effects of TGF-beta on Nb2 cell proliferation.