Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chemical Synapses01:26

Chemical Synapses

10.9K
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
10.9K
Chemical Synapses01:26

Chemical Synapses

4.0K
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
4.0K
Integration of Synaptic Events01:28

Integration of Synaptic Events

3.3K
Synaptic integration mainly includes the summation of graded potentials. Graded potentials, regardless of their type, cause subtle alterations in membrane voltage, resulting in either depolarization or hyperpolarization. These incremental changes, when combined or summed, can propel the neuron toward its threshold. Consider, for example, a membrane experiencing a +15 mV shift, causing it to depolarize from -70 mV to -55 mV. In this scenario, graded potentials govern the membrane's ability to...
3.3K
Excitatory and Inhibitory Effects of Neurotransmitters01:29

Excitatory and Inhibitory Effects of Neurotransmitters

12.2K
When an action potential reaches the presynaptic axon terminal, it releases neurotransmitters from the neuron into the synaptic cleft at a chemical synapse. The released neurotransmitter can be excitatory or inhibitory. The critical criteria commonly used to determine whether a molecule is a neurotransmitter at a chemical synapse are the molecule's presence in the presynaptic neuron. Second, its release is in response to strong presynaptic depolarization. And lastly, the presence of...
12.2K
Synaptic Signaling01:09

Synaptic Signaling

6.3K
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
6.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Varun Venkataramani: the rise of cancer neuroscience.

Nature reviews. Neurology·2026
Same author

IDH status shapes glioma oncotopy: voxel-wise mapping of 644 adult diffuse gliomas.

Neuroradiology·2026
Same author

Author Correction: Multidimensional profiling of heterogeneity in supratentorial ependymomas.

Nature·2026
Same author

Checkpoint Breaches: Unexpected Effects of Anti-PD-1 Therapy on the Blood-Brain Barrier.

Cancer discovery·2026
Same author

Voxel-accurate MRI-microscopy Correlation Enables AI-powered Prediction of Brain Disease States.

Theranostics·2026
Same author

Targeting Tumour Microtubes to Disrupt Glioma Networks.

Research square·2026
Same journal

Mid-term reflections and the growing momentum of Neuro-Oncology.

Neuro-oncology·2026
Same journal

Inferring DNA Methylation Class from Digitized Pathology Images and AI: A Worthy and Timely Application with Room for Improved Clinical Performance.

Neuro-oncology·2026
Same journal

The clinical and molecular landscape of thalamic glioma.

Neuro-oncology·2026
Same journal

MAPK-driven glioma progression and reprogramming of the tumor-associated immune response.

Neuro-oncology·2026
Same journal

Tumor-Targeted pan-RAS Inhibition as a Novel Biologic Therapy for Diffuse Midline Glioma.

Neuro-oncology·2026
Same journal

Corrigendum to: Cellular and in vivo activity of a novel PI3K inhibitor, PX-866, against human glioblastoma.

Neuro-oncology·2026
See all related articles

Related Experiment Video

Updated: Dec 16, 2025

Co-culture of Glutamatergic Neurons and Pediatric High-Grade Glioma Cells Into Microfluidic Devices to Assess Electrical Interactions
07:39

Co-culture of Glutamatergic Neurons and Pediatric High-Grade Glioma Cells Into Microfluidic Devices to Assess Electrical Interactions

Published on: November 17, 2021

3.8K

Synaptic input to brain tumors: clinical implications.

Varun Venkataramani1,2,3, Dimitar Ivanov Tanev1,2,3, Thomas Kuner3

  • 1Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany.

Neuro-Oncology
|July 6, 2020
PubMed
Summary
This summary is machine-generated.

Brain tumors, like gliomas, form synaptic connections with neurons, influencing their growth and invasion. Targeting this neuron-to-brain tumor synaptic communication (NBTSC) offers new therapeutic strategies for incurable brain cancers.

Keywords:
Brain metastasesCancer NeuroscienceDIPGSynapsesglioblastoma

More Related Videos

Surgical Transplantation of Tumor Cells into the Spinal Cord of Mice
05:39

Surgical Transplantation of Tumor Cells into the Spinal Cord of Mice

Published on: December 27, 2024

763
The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma
08:00

The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma

Published on: April 16, 2019

18.9K

Related Experiment Videos

Last Updated: Dec 16, 2025

Co-culture of Glutamatergic Neurons and Pediatric High-Grade Glioma Cells Into Microfluidic Devices to Assess Electrical Interactions
07:39

Co-culture of Glutamatergic Neurons and Pediatric High-Grade Glioma Cells Into Microfluidic Devices to Assess Electrical Interactions

Published on: November 17, 2021

3.8K
Surgical Transplantation of Tumor Cells into the Spinal Cord of Mice
05:39

Surgical Transplantation of Tumor Cells into the Spinal Cord of Mice

Published on: December 27, 2024

763
The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma
08:00

The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma

Published on: April 16, 2019

18.9K

Area of Science:

  • Neuro-oncology
  • Cancer biology
  • Neuroscience

Background:

  • Brain tumors, including gliomas and brain metastases, can integrate into neuronal circuits.
  • Synaptic connections between neurons and tumor cells represent a novel area of research.
  • Understanding these interactions is crucial for developing effective treatments.

Purpose of the Study:

  • To provide an overview of glutamatergic neuron-to-brain tumor synaptic communication (NBTSC).
  • To explore novel therapeutic avenues targeting NBTSC.
  • To discuss future research directions for inhibiting NBTSC.

Main Methods:

  • Review of current literature on neuron-tumor synaptic interactions.
  • Analysis of mechanisms driving tumor growth and invasion via NBTSC.
  • Discussion of therapeutic strategies targeting NBTSC.

Main Results:

  • Direct synaptic interactions exist between neurons and glioma cells.
  • Indirect synaptic input influences metastatic breast cancer cells.
  • NBTSC drives brain tumor growth, invasion, and progression, potentially exacerbating tumor-related epilepsy.

Conclusions:

  • NBTSC is a critical factor in brain tumor progression.
  • Targeting NBTSC presents a promising therapeutic strategy for gliomas and brain metastases.
  • Further research into NBTSC-inhibiting therapies could uncover vulnerabilities in incurable brain tumors.