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A multidisciplinary consensus on the morphological and functional responses to immunotherapy treatment
L Leon-Mateos1, M J Garcia-Velloso2,3, R García-Figueiras4
1Medical Oncology Department, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Servicio Galego de Saude, Santiago de Compostela, Spain.
Summary
Immunotherapy offers new cancer treatments, but identifying patients who benefit remains a challenge. Experts recommend establishing response criteria and biomarkers to guide effective immunotherapy use in oncology.
Area of Science:
- Oncology
- Medical Imaging
- Radiology
Background:
- Immunotherapy has transformed cancer care, expanding treatment options for various malignancies including lung cancer, melanoma, and lymphomas.
- Despite its success, immunotherapy efficacy is limited to a subset of patients, necessitating better patient selection strategies.
Purpose of the Study:
- To provide an updated review and consensus guide on immunotherapy response criteria and biomarkers.
- To address the challenge of identifying patients most likely to benefit from immunotherapy.
Main Methods:
- Consensus review by experts from the Spanish Society of Medical Oncology (SEOM), Spanish Society of Medical Radiology (SERAM), and Spanish Society of Nuclear Medicine and Molecular Imaging (SEMNIM).
Main Results:
- The report synthesizes current knowledge on immunotherapy response assessment and predictive biomarkers.
- It highlights the need for standardized criteria to optimize patient selection for immunotherapy.
Conclusions:
- Establishing clear immunotherapy response criteria and identifying predictive biomarkers are crucial for improving treatment outcomes.
- This consensus guide aims to enhance the application of immunotherapy in clinical oncology practice.
