Related Experiment Video
Updated: Dec 16, 2025
Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
Is there a relationship between serum omentin level and acute phase response in patients with familial Mediterranean
Sevinc Can Sandikci1, Ahmet Omma2, Cigdem Yucel3
1Department of Rheumatology, Ankara Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey. scsandikci@gmail.com.
Objectives:
Familial Mediterranean fever (FMF) is an autoinflammatory disease characterized by frequent attacks and chronic inflammation. Subclinical inflammation continues during the attack-free period. Omentin is an anti-inflammatory adipokine, which plays important roles in the adjustments of glucose metabolism, cardiovascular homeostasis and atherosclerosis. The aim is to investigate the omentin levels in FMF patients and to assess the association with markers of subclinical inflammation in FMF patients such as serum amyloid A (SAA), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP).
Method:
This cross-sectional study included 54 consecutive adult FMF patients (27 male, 27 female) and 28 healthy individuals (16 male, 12 female). The FMF patients were separated into 3 groups: (1) attack-free group, (2) active-attack group and (3) colchicine-resistant group. Serum omentin levels were compared between the FMF patients and the healthy control group.
Results:
A significant difference was determined between the FMF patients and healthy control subjects in terms of omentin levels (108.05 (19.97-343.22) vs. 199.5 (42.98-339.41) p < 0.05). SAA values were significantly higher in the FMF patients compared with the healthy control group. When the FMF patients were examined as separate groups, serum omentin values were lower in the colchicine-resistant group than in the groups without resistance (76.64 (19.77-224.33) vs. 186.47 (28.41-343.21) p = 0.006).
Conclusions:
FMF patients with colchicine resistance are associated with decreased omentin concentrations, probably mediated by inflammation-driven mechanisms. Key Points • Omentin is a type of adipokine which has an anti-inflammatory effect by inhibiting the inflammatory cytokine network. • Decreased omentin levels are associated with increased obesity, insulin resistance and comorbidities. • We report that omentin levels fluctuate in various diseases. In addition, we have focused on the levels of omentin in patients with FMF, as it may act as a biomarker for colchicine resistance.
Insights
Familial Mediterranean Fever (FMF) patients have lower omentin levels, particularly those resistant to colchicine treatment. This suggests omentin may serve as a biomarker for colchicine resistance in FMF.
Area of Science:
- Immunology
- Endocrinology
Background:
- Familial Mediterranean Fever (FMF) is a chronic autoinflammatory disease with persistent subclinical inflammation.
- Omentin, an anti-inflammatory adipokine, influences glucose metabolism, cardiovascular health, and atherosclerosis.
- Investigating omentin in FMF is crucial due to its anti-inflammatory properties.
Purpose of the Study:
- To determine serum omentin levels in FMF patients.
- To evaluate the association between omentin levels and subclinical inflammation markers (SAA, ESR, CRP).
- To explore omentin levels in different FMF patient subgroups, including colchicine resistance.
Main Methods:
- A cross-sectional study involving 54 adult FMF patients and 28 healthy controls.
- FMF patients were categorized into attack-free, active-attack, and colchicine-resistant groups.
- Serum omentin levels were compared between FMF patients and controls, and across FMF subgroups.
Main Results:
- FMF patients exhibited significantly lower serum omentin levels compared to healthy controls.
- Serum amyloid A (SAA) levels were elevated in FMF patients versus controls.
- Colchicine-resistant FMF patients showed significantly lower omentin levels than non-resistant groups.
Conclusions:
- Decreased omentin concentrations in colchicine-resistant FMF patients are likely driven by inflammation.
- Omentin may serve as a potential biomarker for identifying colchicine resistance in FMF.
- Omentin's role in inflammation and its association with comorbidities highlight its significance in FMF management.
Related Concept Videos
01:17Gastritis-II: Pathophysiology
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
01:27Myocarditis II: Clinical Features and Diagnostic Tests
01:19Pericarditis II: Clinical Features and Diagnostic Tests
01:23Gastritis III: Clinical Manifestations and Management
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
01:30Acute Pancreatitis II: Clinical Manifestations and Management
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies