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Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application
Published on: September 27, 2024
Non surgical facial reshaping using MD Codes
Dario Bertossi1, Pier Francesco Nocini1, Eqram Rahman2
1Department of Oral and Maxillofacial Surgery, Policlinico G.B. Rossi, University of Verona, Verona, Italy.
This study evaluated a new method called the MD Codes approach for facial rejuvenation using hyaluronic acid fillers and onabotulinumtoxinA. Researchers looked at 250 patients who received these treatments and found that the approach led to noticeable improvements in appearance. The study also found that the treatment was generally safe, with common side effects like bruising and swelling that resolved on their own. The results suggest that the MD Codes approach could be a reliable and effective way to rejuvenate the face without surgery.
Area of Science:
- Aesthetic medicine outcomes research within dermatology
- Non-surgical facial rejuvenation techniques in cosmetic surgery
- Injectable filler applications in facial contouring
Background:
Established clinical practices use hyaluronic acid (HA) fillers to address facial volume loss. These treatments typically involve deep injection for structural support and superficial injection for contouring. However, a standardized protocol for full-face rejuvenation has remained limited. Prior research has shown that HA fillers and onabotulinumtoxinA can improve facial aesthetics, but the specific combination and placement remain underexplored. This gap motivated the development of the MD Codes approach as a potential framework for full-face rejuvenation. No prior work had resolved how to systematically apply HA fillers and onabotulinumtoxinA across multiple facial regions. The need for a reproducible methodology led to this retrospective study. The study aimed to assess whether a structured injection protocol could yield consistent aesthetic outcomes. The absence of a widely accepted protocol for full-face rejuvenation created a need for further investigation.
Purpose Of The Study:
The study aimed to evaluate the clinical efficacy, patient satisfaction, and safety of the MD Codes approach for full-face rejuvenation. This method proposes a standardized injection protocol using HA fillers and onabotulinumtoxinA. The specific problem addressed was the lack of a reproducible framework for facial rejuvenation. The motivation stemmed from the need to provide a consistent and effective treatment plan. The study focused on whether the MD Codes approach could deliver measurable aesthetic improvements. The researchers sought to determine if this method could be safely applied across multiple facial regions. The study also aimed to quantify patient satisfaction and assess potential complications. The goal was to establish a validated protocol for non-surgical facial rejuvenation.
Main Methods:
This study used a retrospective, single-center design to assess the MD Codes approach. A total of 250 consecutive patients received HA fillers and onabotulinumtoxinA treatments. The study population included adults with a mean age of 39.4 ± 11.6 years, with 80.4% being female. Treatments followed a structured protocol based on the MD Codes system. HA fillers were injected into the midface region for all patients. Additional injections occurred in the upper and lower face regions for a subset of patients. OnabotulinumtoxinA was administered to all participants as part of the treatment plan. Patient outcomes were measured using the FACE-Q Appearance-Related Psychosocial Distress score. Complications were recorded and analyzed to assess treatment safety.
Main Results:
The study found that the MD Codes approach led to significant aesthetic improvements. The mean number of HA filler syringes used was 14 ± 4, with older patients requiring more syringes. The FACE-Q score decreased from 54.3 ± 9.3 pre-treatment to 36.1 ± 8.9 at 3 months post-treatment (P < 0.05). These results suggest a notable improvement in appearance-related distress. The most common complications included bruising (35.2%) and transient soft-tissue edema (14.0%). Prolonged periorbital edema occurred in 3.6% of cases. No major safety issues were observed during the study period. The findings support the clinical viability of the MD Codes approach for full-face rejuvenation.
Conclusions:
The MD Codes approach for full-face rejuvenation provides significant aesthetic improvements. The study observed a decrease in appearance-related distress scores over time. No major safety concerns were reported in the patient cohort. The treatment protocol involved HA fillers and onabotulinumtoxinA administered in a structured manner. The most common complications were bruising and transient edema, which resolved without intervention. The findings suggest that the MD Codes approach is a safe and effective treatment option. The observed improvements in patient satisfaction support the use of this standardized protocol. The study does not propose future directions or drug targets beyond the treatment outcomes observed.
Frequently Asked Questions
The MD Codes approach is a standardized protocol for full-face rejuvenation using HA fillers and onabotulinumtoxinA. It specifies injection sites and product volumes for consistent aesthetic outcomes.
The mean number of syringes used was 14 ± 4, with older patients generally requiring more syringes than younger patients.
OnabotulinumtoxinA was included to complement HA filler injections, likely to address dynamic wrinkles and enhance overall facial contouring.
The most common complication was bruising, occurring in 35.2% of patients, followed by transient soft-tissue edema in 14.0% of cases.
Patient satisfaction was measured using the FACE-Q Appearance-Related Psychosocial Distress score, which decreased significantly after treatment.
The decrease in FACE-Q scores suggests that patients experienced reduced appearance-related distress following treatment with the MD Codes approach.

