Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Evidence for Evolution02:55

The Evidence for Evolution

47.2K
Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
47.2K
Psychology as a Science01:13

Psychology as a Science

3.6K
Psychology, as a scientific discipline, aims to understand the mind and behavior through rigorous and systematic methods. The foundation of psychological research is evidence-based, relying heavily on the scientific method to derive and validate knowledge. This structured approach ensures that findings are reliable, valid, and applicable to broader contexts.
The scientific method in psychology involves six critical steps: making observations, formulating hypotheses, conducting tests, analyzing...
3.6K
The Scientific Method in Nursing Process01:18

The Scientific Method in Nursing Process

15.3K
The scientific method provides the foundation for any research. It is the most reliable and objective of all forms of gaining knowledge and guides in applying research-based evidence in practice and conducting future research.
When using research findings to change practice, one must understand the process used to guide a study. The scientific method is a systematic, step-by-step process that supports the data's validity, reliability, and generalizability. As a result, findings can be...
15.3K
The Scientific Method02:40

The Scientific Method

64.4K
Research is what makes the difference between facts and opinions. Facts are observable realities, and opinions are personal judgments, conclusions, or attitudes that may or may not be accurate. In the scientific community, facts can be established only using evidence collected through empirical research.
64.4K
The Scientific Method01:32

The Scientific Method

254.9K
The scientific method is a detailed, empirical problem-solving process used by biologists and other scientists. This iterative approach involves formulating a question based on observation, developing a testable potential explanation for the observation (called a hypothesis), making and testing predictions based on the hypothesis, and using the findings to create new hypotheses and predictions.
Generally, predictions are tested using carefully-designed experiments. Based on the outcome of these...
254.9K
The Scientific Method03:50

The Scientific Method

63.9K
Chemistry is an empirical science. Scientists often pose questions to understand the chemistry in everyday life and seek answers to these questions. To achieve this, scientists follow a definitive series of steps that together make up the Scientific Method. This approach involves making observations, asking questions, building a hypothesis, conducting experiments, analyzing results, and forming a conclusion. 
63.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modeling human embryo adhesion using a microfluidic platform.

Science advances·2026
Same author

American College of Chest Physicians algorithm for lung resective surgery: Real-life validation.

Pulmonology·2026
Same author

Autologous cell therapy with CD133+ bone marrow-derived stem cells for Asherman Syndrome: a phase 1/2 trial.

Nature communications·2026
Same author

Intravenous Lidocaine Modulates the Perioperative Hepatic Inflammatory Response: Implications for Personalized Medicine in Thoracic Surgery.

Journal of personalized medicine·2025
Same author

Capturing aberrant cell behaviors producing defects in human embryos via live imaging.

Science advances·2025
Same author

Lidocaine Attenuates miRNA Dysregulation and Kinase Signaling Activation in a Porcine Model of Lung Ischemia/Reperfusion Injury.

International journal of molecular sciences·2025

Related Experiment Video

Updated: Dec 16, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
05:47

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

1.1K

Introduction: How evident is the evidence?

Carlos Simon1

  • 1Department of Pediatrics, Obstetrics, and Gynecology, University of Valencia, Valencia, Spain; Igenomix Foundation-Instituto de Investigación Sanitaria INCLIVA, Valencia, Spain; Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Harvard University, Boston, Massachusetts.

Fertility and Sterility
|July 7, 2020
PubMed
Summary
This summary is machine-generated.

High-quality randomized controlled trials (RCTs) and meta-analyses are crucial for evidence-based medicine. Ensuring their integrity and performance is vital to avoid harmful consequences in patient care.

Keywords:
Randomized controlled trialsevidencemeta-analysisreproductive medicineresearch integrity

More Related Videos

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI
06:26

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI

Published on: November 27, 2019

76.2K
Comparing Bibliometric Analysis Using PubMed, Scopus, and Web of Science Databases
05:02

Comparing Bibliometric Analysis Using PubMed, Scopus, and Web of Science Databases

Published on: October 24, 2019

33.2K

Related Experiment Videos

Last Updated: Dec 16, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
05:47

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

1.1K
Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI
06:26

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI

Published on: November 27, 2019

76.2K
Comparing Bibliometric Analysis Using PubMed, Scopus, and Web of Science Databases
05:02

Comparing Bibliometric Analysis Using PubMed, Scopus, and Web of Science Databases

Published on: October 24, 2019

33.2K

Area of Science:

  • Reproductive Medicine
  • Evidence-Based Medicine
  • Clinical Research Methodology

Background:

  • Randomized controlled trials (RCTs) and meta-analyses are foundational to evidence-based medicine.
  • Their utility in clinical practice and policy relies heavily on quality, performance, and integrity.
  • Reproductive medicine specifically benefits from rigorous evaluation of these study types.

Purpose of the Study:

  • To educate readers on the essential features guaranteeing the quality of RCTs and meta-analyses.
  • To discuss the global status, unmet needs, and future directions for RCTs in reproductive medicine.
  • To address challenges related to data fabrication and falsification, proposing solutions for maintaining research integrity.

Main Methods:

  • A comprehensive review and expert consensus on RCT and meta-analysis quality.
  • Discussion of trial protocols, registration, monitoring, design, analysis, and reporting standards.
  • Exploration of methodological issues, global coordination, and integrity concerns in reproductive medicine research.

Main Results:

  • Identified key quality indicators for RCTs and meta-analyses.
  • Highlighted current challenges in planning, coordination, and methodological execution of trials.
  • Addressed the critical issue of data fabrication and falsification, emphasizing the need for robust integrity measures.

Conclusions:

  • The quality, performance, and integrity of RCTs and meta-analyses are paramount for reliable medical evidence.
  • Addressing methodological challenges and ensuring data integrity are crucial for advancing reproductive medicine.
  • Education and vigilance are necessary to uphold the "magic" of these evidence-generating tools and prevent patient harm.