Related Experiment Video
Updated: Dec 16, 2025

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
Published on: November 23, 2014
The emerging role of EGFL6 in angiogenesis and tumor progression
Jing Kang1, Juanjuan Wang1, Jihua Tian1
1Department of Microbiology and Immunology, Shanxi Medical University, Taiyuan, Shanxi, China.
Abstract:
Epidermal growth factor-like domain-containing protein 6 (EGFL6) belongs to the epidermal growth factor (EGF) superfamily. EGFL6 is expressed at higher levels in embryos and various malignant tumors than in normal tissues. Recent studies suggest that EGFL6 participates in the development of a variety of tumors. In this review, we summarize findings that support the role for EGFL6 in tumor proliferation, invasion and migration. Furthermore, our review results indicate the mechanism of EGFL6 activity angiogenesis. We also describe work toward the preparation of monoclonal antibodies against EGFL6. Altogether, the work of this review promotes understanding of the role of EGFL6 in tumor development, the mechanism of that action, and the potential of EGFL6 as a therapeutic target for tumor prevention and treatment.
Related Concept Videos
Regulation of Angiogenesis and Blood Supply
Mitogens and the Cell Cycle
Mechanism of Angiogenesis
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
The Tumor Microenvironment

