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Updated: Dec 16, 2025

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release
Published on: June 12, 2021
Determination of bubble size distribution in gas-liquid two-phase systems via an ultrasound-based method
Xue Chen1, Mohamed Hussein1, Thomas Becker2
1Bio-Process Analysis Technology Chair of Brewing and Beverage Technology Technische Universität München Freising Weihenstephan Germany.
Abstract:
Over the past few years, ultrasonic techniques are increasingly used to determine bubble size distribution in gas-liquid two-phase systems. However, the development of a precise and efficient measuring system is very challenging because bubbles are dynamic and unstable relative to time and space in a moving fluid, thus hindering an accurate validation of the measuring system. Therefore, this study examined the possibility of using artificial bubbles to establish an ultrasonic measuring system. The main concept for this study involved developing an ultrasound-based measuring system with the aid of a certain type of artificial bubbles. The developed system was subsequently adapted to the bypass pipeline of a propagator to demonstrate the reliability of this concept. The results indicated that the established system could measure a microbubble size distribution with a root mean squared error of validation that corresponded to 0.1243 % v/v. Additionally, the estimates of real bubble measurement agreed well with the reference method. Thus, this study demonstrated that the developed system could be a potential method to determine bubble size distributions in gas-liquid two-phase systems.
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