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Dietary Reference Values for riboflavin.

, Dominique Turck, Jean-Louis Bresson

    EFSA Journal. European Food Safety Authority
    |July 7, 2020
    PubMed
    Summary
    This summary is machine-generated.

    This study establishes new dietary reference values (DRVs) for riboflavin (vitamin B2) intake. The findings provide updated recommendations for adequate riboflavin status across various age groups and life stages.

    Keywords:
    average requirementbiomarkerdietary reference valueglutathione reductasepopulation reference intakeriboflavinurinary excretion

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    Area of Science:

    • Nutrition Science
    • Dietary Reference Values
    • Vitamin Metabolism

    Background:

    • Riboflavin (vitamin B2) is essential for numerous metabolic processes.
    • Establishing accurate dietary reference values (DRVs) is crucial for public health.
    • Previous DRVs required updates based on current scientific understanding.

    Purpose of the Study:

    • To derive new dietary reference values (DRVs) for riboflavin for different population groups.
    • To identify reliable biomarkers for assessing adequate riboflavin status.
    • To provide evidence-based recommendations for European populations.

    Main Methods:

    • Utilized urinary riboflavin excretion inflection points as a biomarker for body saturation.
    • Employed erythrocyte glutathione reductase activation coefficient as a secondary biomarker.
    • Applied weighted mean analysis of intake data from intervention studies.
    • Extrapolated and scaled requirements for infants and children using allometric methods.

    Main Results:

    • Established average requirements (ARs) and population reference intakes (PRIs) for adults at 1.3 mg/day and 1.6 mg/day, respectively.
    • Set adequate intake for infants (7-11 months) at 0.4 mg/day.
    • Defined ARs for children (1-17 years) ranging from 0.5-1.4 mg/day and PRIs from 0.6-1.6 mg/day.
    • Derived PRIs for pregnant (1.9 mg/day) and lactating (2.0 mg/day) women.

    Conclusions:

    • Urinary riboflavin excretion inflection point is a reliable indicator of adequate riboflavin status.
    • The derived DRVs provide updated nutritional guidelines for riboflavin intake.
    • Recommendations account for specific physiological needs during pregnancy, lactation, and growth stages.