Statement on the safety of d-ribose
EFSA Journal. European Food Safety Authority
|July 7, 2020
Summary
D-ribose is now considered safe as a novel food ingredient for the general population. This updated assessment confirms safety under new proposed uses and intake levels, following initial concerns.
Area of Science:
- Food Safety
- Nutritional Science
- Regulatory Science
Background:
- The European Food Safety Authority (EFSA) initially assessed d-ribose in 2018, deeming it safe up to 36 mg/kg body weight (bw) per day but unable to confirm safety for proposed uses.
- A subsequent request from the European Commission prompted a supplementary safety assessment for d-ribose.
Purpose of the Study:
- To conduct a supplementary safety assessment of d-ribose, considering new proposed uses and intake levels.
- To re-evaluate the safety of d-ribose as a novel food ingredient.
Main Methods:
- An intake assessment was performed using individual data from the EFSA Comprehensive European Food Consumption Database.
- D-ribose intake was estimated across all age groups within the general population.
Main Results:
- Estimated mean and high-level intakes of d-ribose generally remained below the previously established safe level of 36 mg/kg bw per day.
- A single survey on adolescents showed mean and 95th percentile intakes of 8.6 and 39.4 mg/kg bw per day, respectively, slightly exceeding the threshold in high-level consumers.
Conclusions:
- D-ribose is considered safe as a novel food under the newly proposed conditions of use.
- The supplementary assessment supports the safety of d-ribose for the general population at the specified intake levels.
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