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Circulating Sestrin Levels Are Increased in Hypertension Patients
Cao Fang1, Zicong Yang2, Lei Shi2
1Xishui County People's Hospital Affiliated to Hubei University of Science and Technology, Hubei 530021, China.
Disease Markers
|July 7, 2020
Summary
Plasma levels of sestrins (Sesns) are elevated in hypertension patients, increasing with hypertension severity. These oxidative stress-related proteins may serve as biomarkers for hypertension prevention and treatment.
Area of Science:
- Cardiovascular Medicine
- Biochemistry
- Oxidative Stress Research
Background:
- Sestrins (Sesns) are oxidative stress-related proteins implicated in cardiovascular diseases.
- Previous research links sestrin family proteins to conditions like aortic dissection and chronic heart failure.
Purpose of the Study:
- To investigate circulating levels of Sesn1, Sesn2, and Sesn3 in patients diagnosed with hypertension.
- To explore the relationship between sestrin levels and hypertension severity and associated clinical factors.
Main Methods:
- Plasma samples from 400 hypertensive patients and 100 normotensive controls were analyzed using enzyme-linked immunosorbent assay (ELISA).
- Hypertension patients were stratified by grade (I, II, III) and categorized based on dipping status.
- Correlations with blood pressure, smoking, angiotensin II (Ang II), and carotid atherosclerotic plaque (CAP) were examined.
Main Results:
- Sesn1, Sesn2, and Sesn3 levels were significantly higher in hypertensive patients compared to normotensive controls.
- A gradual increase in sestrin levels was observed with increasing hypertension grade (I to III).
- Elevated sestrin levels correlated positively with systolic and diastolic blood pressure, and were further increased in non-dipper hypertension, smokers, and patients with higher Ang II and CAP levels.
Conclusions:
- Circulating sestrin levels are elevated in hypertension patients.
- Sestrin levels show a positive correlation with hypertension severity and related clinical markers.
- Sesn proteins may represent a potential therapeutic target for managing clinical hypertension.
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