Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diversity of Protists II01:27

Diversity of Protists II

676
Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...
676
The Electron Transport Chain01:30

The Electron Transport Chain

19.2K
The electron transport chain or oxidative phosphorylation is an exothermic process in which free energy released during electron transfer reactions is coupled to ATP synthesis. This process is a significant source of energy in aerobic cells, and therefore inhibitors of the electron transport chain can be detrimental to the cell's metabolic processes.
Inhibitors of the electron transport chain
Rotenone, a widely used pesticide, prevents electron transfer from Fe-S cluster to ubiquinone or Q...
19.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Global Roll-Out and Continued Multi-Site Validation of the Artificial Intelligence Histology Instrument for Qualitative Assessment of Histopathology in Ulcerative Colitis.

United European gastroenterology journal·2026
Same author

Cryo-electron tomography reveals paracellular claudin-15 pores at the tight junction.

Biophysical journal·2026
Same author

The OCTN2 transporter can be targeted by carnitine functionalised non-ionic surfactant vesicles to deliver drugs across the blood-brain barrier.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

Inflammation-Induced Claudin-2 Up-Regulation Limits Pancreatitis Development by Enhancing Pancreatic Ductal Transport.

Gastroenterology·2026
Same author

Second-Generation Anti-Tubercular Squaramides Targeting Complex V of the Respiratory Chain of <i>Mycobacterium tuberculosis</i> Displaying Enhanced Metabolic Stability.

Journal of medicinal chemistry·2026
Same author

Glutamine-dependent changes in fibroblast-derived extracellular matrix dictate cancer cell behavior.

Matrix biology : journal of the International Society for Matrix Biology·2026

Related Experiment Video

Updated: Dec 16, 2025

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds
07:14

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds

Published on: July 11, 2025

447

Potent Tetrahydroquinolone Eliminates Apicomplexan Parasites.

Martin J McPhillie1, Ying Zhou2, Mark R Hickman3

  • 1School of Chemistry, The University of Leeds, Leeds, United Kingdom.

Frontiers in Cellular and Infection Microbiology
|July 7, 2020
PubMed
Summary

A novel compound, JAG21, shows promise in treating apicomplexan infections like toxoplasmosis and malaria. This tetrahydroquinolone effectively reduces parasite load and offers 100% survival in murine models, demonstrating broad therapeutic potential.

Keywords:
Plasmodium falciparumRPS13ΔToxoplasma gondiicytochrome bc1nanoformulationstructure-guided designtetrahydroquinolonetranscriptomics

More Related Videos

Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases
09:13

Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases

Published on: November 22, 2024

1.7K
High Yield Purification of Plasmodium falciparum Merozoites For Use in Opsonizing Antibody Assays
10:38

High Yield Purification of Plasmodium falciparum Merozoites For Use in Opsonizing Antibody Assays

Published on: July 17, 2014

23.5K

Related Experiment Videos

Last Updated: Dec 16, 2025

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds
07:14

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds

Published on: July 11, 2025

447
Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases
09:13

Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases

Published on: November 22, 2024

1.7K
High Yield Purification of Plasmodium falciparum Merozoites For Use in Opsonizing Antibody Assays
10:38

High Yield Purification of Plasmodium falciparum Merozoites For Use in Opsonizing Antibody Assays

Published on: July 17, 2014

23.5K

Area of Science:

  • Medicinal Chemistry
  • Parasitology
  • Drug Discovery

Background:

  • Apicomplexan parasites cause significant global disease burden.
  • Existing therapies for toxoplasmosis and malaria are limited, necessitating new treatments.

Purpose of the Study:

  • To develop a next-generation anti-apicomplexan compound with improved selectivity and properties.
  • To evaluate the efficacy of the novel compound JAG21 against apicomplexan parasites.

Main Methods:

  • Synthesis and characterization of tetrahydroquinolone compound JAG21.
  • In vitro and in vivo testing against *Toxoplasma gondii* and *Plasmodium falciparum*.
  • Enzymatic, binding, and co-crystallography studies for mechanism of action and selectivity.

Main Results:

  • JAG21 demonstrated significant reduction of *T. gondii* tachyzoites and bradyzoites in vitro and in murine models, achieving 100% survival.
  • JAG21 showed efficacy against drug-resistant *P. falciparum* in vitro.
  • Single oral dose or short-term treatment of JAG21 provided causal prophylaxis and radical cure in *P. berghei* infected mice, with 100% survival.

Conclusions:

  • JAG21 exhibits potent anti-apicomplexan activity and favorable ADMET properties.
  • The compound displays selectivity for apicomplexan enzymes over mammalian counterparts.
  • JAG21 is a promising pre-clinical candidate for treating and preventing toxoplasmosis and malaria.