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2-Methoxyethanol: harmonic tricks, anharmonic challenges and chirality-sensitive chain aggregation.

Maxim Gawrilow¹, Martin A Suhm

¹Institut für Physikalische Chemie, Georg-August-Universität Göttingen, Tammannstr. 6, 37077 Göttingen, Germany. msuhm@gwdg.de.

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Summary

Investigating 2-methoxyethanol

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Area of Science:

Physical Chemistry
Molecular Spectroscopy
Computational Chemistry

Background:

Understanding molecular conformation and aggregation is crucial in chemistry.
2-methoxyethanol is a model system for studying hydrogen bonding and conformational dynamics.
Chirality influences intermolecular interactions in molecular systems.

Purpose of the Study:

To investigate the aggregation-sensitive backbone stretching and chirality-dependent dimerisation of 2-methoxyethanol.
To disentangle spectral features using a dual-detection scheme.
To evaluate computational methods for predicting vibrational spectra.

Main Methods:

Jet-cooled Raman spectroscopy
Dual-detection spectroscopy
Mass-scaled harmonic wavenumber predictions
Vibrational perturbation theory

Main Results:

A strong, aggregation-sensitive resonance was observed in the backbone stretching region.
Pronounced chirality-dependent dimerisation effects were identified in the OH stretching region.
The dual-detection scheme successfully disentangled these spectral features.

Conclusions:

The study provides insights into the conformational behavior and intermolecular interactions of 2-methoxyethanol.
Computational methods show varying performance in reproducing experimental spectral features.
Dual-detection spectroscopy is effective for analyzing complex molecular systems.