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Published on: August 1, 2018
Intramolecularly stapled amphipathic peptides via a boron-sugar interaction
Monika Kijewska1, Angelika Czerwińska, Samah Al-Harthi
1Faculty of Chemistry, University of Wrocław, Joliot-Curie 14, 50-383 Wrocław, Poland. monika.kijewska@chem.uni.wroc.pl.
Abstract:
Amadori products (deoxyfructosyllysine derivatives) that can selectively interact with phenylboronic acids and borate ions were synthesized. The intramolecular interactions between the fructosyl moiety and phenylboronic acid incorporated into various positions of the peptide chain were investigated using high-resolution mass spectrometry (HR-MS), circular dichroism (CD), and nuclear magnetic resonance (NMR).
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