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Updated: Dec 15, 2025

Engineering Three-dimensional Epithelial Tissues Embedded within Extracellular Matrix

Engineering Three-dimensional Epithelial Tissues Embedded within Extracellular Matrix

Published on: July 10, 2016

Engineering and modeling of multicellular morphologies and patterns.

Honesty Kim¹, Xiaofan Jin², David S Glass³

¹Department of Molecular and Cellular Biology, University of Arizona, Tucson, USA.

Current Opinion in Genetics & Development

|July 7, 2020

Summary

This summary is machine-generated.

Synthetic multicellular systems offer insights into biofilms and organisms, enabling new applications in medicine and materials. Future work focuses on improving parts, algorithms, and modeling for practical synthetic biology engineering.

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Last Updated: Dec 15, 2025

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Area of Science:

Synthetic Biology
Bioengineering
Systems Biology

Background:

Synthetic multicellular (MC) systems are crucial for understanding biofilms and higher organisms.
They serve as engineering platforms for medicine, biosynthesis, and smart materials.
Emerging approaches focus on engineering and modeling these complex systems.

Purpose of the Study:

To provide an interdisciplinary review of emerging approaches in synthetic MC systems.
To define key terms and identify toolboxes of standardized parts for MC algorithms.
To outline future milestones for advancing MC engineering.

Main Methods:

Review of interdisciplinary perspectives on MC systems engineering and modeling.
Identification and definition of standardized parts and algorithms.
Analysis of current advancements and future directions.

Main Results:

Definitions for key terms in synthetic MC systems are established.
Toolboxes of standardized parts for MC algorithms are identified.
Demonstrated potential for various MC algorithms and essential parts.

Conclusions:

Synthetic MC systems hold significant potential for scientific understanding and technological innovation.
Key next steps include improving parts, developing complex algorithms, and advancing quantitative modeling.
Implementation of MC engineering is crucial for practical applications in diverse fields.