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Cu2+-selective NIR fluorescence sensor based on heptamethine cyanine in aqueous media and its application
Oranual Hanmeng1, Nirumon Chailek1, Adisri Charoenpanich2
1Department of Chemistry, Faculty of Science, Silpakorn University, Nakhon Pathom 73000, Thailand.
Abstract:
A near-infrared (NIR) colorimetric fluorescence sensor, Cy7C3, based on heptamethine cyanine dye was synthesized for determining the presence of Cu2+ ions. The sensor showed highly sensitive fluorescence quenching toward Cu2+ ions in acetonitrile/buffer solution at physiological pH with long emission wavelength of 718 nm. Cy7C3 also provided an excellent selectivity to Cu2+ ions over other competing metal ions, with a low detection limit of 9 ppb, which was lower than the maximum concentration of Cu2+ ions in drinking water of U.S. EPA. Cy7C3 could achieve naked-eye detection of Cu2+ ions via the color change from blue to colorless, which allowed determination of Cu2+ ions in hydroponic fertilizers. Additionally, the sensor was developed to detect Cu2+ ions in HepG2 cancer cells via fluorescence imaging.

