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Related Experiment Video

Updated: Dec 15, 2025

Author Spotlight: Radiotherapy and Clonogenic Assays for Advancing Cancer Research and Personalized Medicine
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Damage-associated molecular patterns in tumor radiotherapy.

Milad Ashrafizadeh1, Bagher Farhood2, Ahmed Eleojo Musa3

  • 1Department of Basic Science, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.

International Immunopharmacology
|July 7, 2020
PubMed
Summary

Radiotherapy triggers cancer cell death, releasing danger signals (DAMPs). These DAMPs influence tumor growth and immune response, offering potential targets for combined cancer therapies.

Keywords:
AdenosineDamage-associated molecular patterns (DAMPs)ImmunotherapyNeoplasmRadiotherapyTumor

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Area of Science:

  • Oncology
  • Immunology
  • Radiotherapy Research

Background:

  • Radiotherapy is a cornerstone of cancer treatment.
  • Radiotherapy can induce immunologic cell death, releasing damage-associated molecular patterns (DAMPs).
  • DAMPs play a dual role in the tumor microenvironment (TME), influencing tumor growth and immune responses.

Purpose of the Study:

  • To review the mechanisms of radiation-induced DAMP release.
  • To explore the consequences of DAMPs on tumor cells and the TME.
  • To discuss the potential of targeting DAMPs in combination cancer therapy.

Main Methods:

  • Literature review of radiotherapy effects on DAMPs.
  • Analysis of DAMPs' roles in tumor microenvironment.
  • Exploration of therapeutic strategies involving DAMPs.

Main Results:

  • Radiotherapy releases various DAMPs, including heat shock proteins (HSPs), high mobility group box 1 (HMGB1), and adenosine.
  • DAMPs can promote or suppress tumor growth and affect radiotherapy resistance.
  • Adenosine, a DAMP metabolite, can enhance tumor growth and radioresistance.

Conclusions:

  • Understanding radiation-induced DAMPs is crucial for cancer treatment.
  • Targeting DAMPs presents a promising strategy for enhancing radiotherapy and radioimmunotherapy efficacy.
  • Further research into DAMP-mediated mechanisms can optimize combination cancer therapies.