Dark Proteome Database: Studies on Disorder
Nelson Perdigão1, Pedro M C Pina1, Cátia Rocha1
1Instituto de Sistemas e Robótica, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal.
High-Throughput
|July 8, 2020
Abstract:
There is a misconception that intrinsic disorder in proteins is equivalent to darkness. The present study aims to establish, in the scope of the Swiss-Prot and Dark Proteome databases, the relationship between disorder and darkness. Three distinct predictors were used to calculate the disorder of Swiss-Prot proteins. The analysis of the results obtained with the used predictors and visualization paradigms resulted in the same conclusion that was reached before: disorder is mostly unrelated to darkness.
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