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A Census and Categorization Method of Epitranscriptomic Marks.

Julia Mathlin1, Loredana Le Pera2,3, Teresa Colombo3

  • 1Department of Life Sciences and Medicine, University of Luxembourg, L-4367 Belvaux, Luxembourg.

International Journal of Molecular Sciences
|July 8, 2020
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Summary
This summary is machine-generated.

Epitranscriptomics studies cellular RNA modifications, impacting gene expression and linked to diseases. A new classification system is proposed to organize discovered RNA modifications, aiding future research.

Keywords:
RNA modificationsepigenetic regulationepitranscriptomeepitranscriptomicsgene-expression regulationpost-transcriptional regulation

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Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • The study of chemical modifications on cellular ribonucleic acid (RNA) is a rapidly growing field, termed epitranscriptomics.
  • Epitranscriptomics investigates RNA modifications as a post-transcriptional regulatory layer of gene expression, involving RNA-binding proteins (RBPs).
  • Several RNA modifications affecting gene expression have been identified across various RNA types, with links to human diseases.

Purpose of the Study:

  • To review current knowledge on epitranscriptomic marks.
  • To propose a novel categorization method for RNA modifications.
  • To provide a framework for organizing the expanding landscape of epitranscriptomic discoveries.

Main Methods:

  • Literature review of epitranscriptomic research.
  • Development of a classification system based on ribonucleotide modifications and "stages" of alteration.
  • Analysis of existing data on RNA modifications and associated RBPs.

Main Results:

  • Identification and characterization of various epitranscriptomic marks across different RNA species.
  • Association of RNA modifications and RBPs with human diseases, highlighting functional relevance.
  • Proposal of a systematic classification scheme for RNA modifications.

Conclusions:

  • Epitranscriptomics represents a crucial regulatory layer in gene expression.
  • A standardized classification system is needed to organize the growing number of discovered RNA modifications.
  • Technological advancements, particularly in sequencing, are expected to accelerate epitranscriptomic research and characterization.