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Related Concept Videos

Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

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Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
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Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

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Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
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Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

192
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
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Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

441
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
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Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
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Erectile Dysfunction after Kidney Transplantation.

Anna Perri1, Giulia Izzo2, Danilo Lofaro1

  • 1Kidney and Transplantation Research Center, Department of Nephrology, Dialysis and Transplantation, Annunziata Hospital, 87100 Cosenza, Italy.

Journal of Clinical Medicine
|July 8, 2020
PubMed
Summary
This summary is machine-generated.

Erectile dysfunction is common after kidney transplantation, impacting quality of life. Treatments like testosterone therapy, PDE5 inhibitors, alprostadil, and penile prostheses can effectively manage this condition.

Keywords:
end-stage renal diseasehypogonadismintracavernous injectionphosphodiesterase type-5 inhibitorsprolactin

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Area of Science:

  • Nephrology
  • Urology
  • Endocrinology

Background:

  • Kidney transplant recipients often experience diminished quality of life, particularly males suffering from erectile dysfunction (ED).
  • ED post-transplant stems from comorbidities, surgical factors, medication side effects, psychological distress, and hormonal imbalances like hyperprolactinemia and hypogonadism.

Purpose of the Study:

  • To review treatment options for erectile dysfunction in male kidney transplant recipients.
  • To assess the safety and efficacy of various ED treatments in the context of post-kidney transplant care.

Main Methods:

  • Review of existing literature on ED management in kidney transplant patients.
  • Analysis of the impact of common ED pharmacotherapies (PDE5 inhibitors, alprostadil) and surgical options (penile prostheses) on transplant recipients.

Main Results:

  • Testosterone replacement therapy is indicated for endocrine dysfunctions post-transplant.
  • Sildenafil (a PDE5 inhibitor) does not significantly affect calcineurin inhibitor pharmacokinetics or kidney allograft function, but caution is advised with tacrolimus due to potential adverse interactions.
  • Alprostadil (intracavernous or topical) offers a safe second-line treatment without impacting cyclosporine levels or kidney function.
  • Penile prosthesis implantation is a viable option after pelvic organ transplantation, provided infection risks are managed.

Conclusions:

  • Erectile dysfunction is a significant concern for male kidney transplant recipients, requiring tailored management strategies.
  • Pharmacological and surgical interventions can effectively address ED, with careful consideration of drug interactions and patient-specific factors.
  • Optimizing ED treatment contributes to improved quality of life for kidney transplant survivors.